Document Detail

Effects of cardioselective beta blockade on the peripheral lung in guinea pigs.
MedLine Citation:
PMID:  2896599     Owner:  NLM     Status:  MEDLINE    
Impairment of lung function with selective beta-1 blocking drugs has been repeatedly demonstrated in guinea pigs, normal subjects and asthmatic patients. The effects of several beta blockers, propranolol (non-selective), atenolol (beta-1 selective), IPS 339 (beta-2 selective) on histamine-induced bronchoconstriction have been investigated in 30 anaesthetized and mechanically ventilated guinea pigs, measuring changes in conductance and dynamic compliance. Their effects on peripheral lung, where only beta-2 adrenoceptors are present, were more specifically assessed using changes in lung distensibility by means of static pressure-volume curves. Atenolol (1, IPS 339 (2 and propranolol (2 enhanced histamine-induced decrease in lung distensibility, conductance and dynamic compliance. The decrease was of the same order of magnitude for all three parameters. Atenolol (1 and propranolol (2 decreased lung distensibility to the same extent. By contrast low dose atenolol (0.1 did not potentiate histamine-induced bronchoconstriction although this dose did produce a significant cardiac beta blockade. These results demonstrate that 1) beta blockers have a clear effect on the peripheral lung, 2) beta-1 adrenoceptors are not involved in pulmonary effects of cardioselective drugs. They suggest that dose dependent loss of selectivity is the major mechanism behind impairment of lung function following such drugs.
C Clerici; I Macquin-Mavier; A Harf
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  1     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-06-16     Completed Date:  1988-06-16     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  10-4     Citation Subset:  IM    
Laboratoire de Physiologie, INSERM U 296 and Service de Pharmacologie Clinique, Hôpital Henri Mondor, Créteil, France.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology*
Atenolol / pharmacology
Bronchi / drug effects
Dose-Response Relationship, Drug
Drug Synergism
Guinea Pigs
Heart Rate / drug effects
Histamine / pharmacology
Isoproterenol / pharmacology
Lung / drug effects*
Lung Compliance / drug effects
Propanolamines / pharmacology
Propranolol / pharmacology
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Propanolamines; 29122-68-7/Atenolol; 51-45-6/Histamine; 525-66-6/Propranolol; 60979-28-4/IPS 339; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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