| Effects of cardiopulmonary bypass surgery on coronary flow in children assessed with transthoracic Doppler echocardiography. | |
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MedLine Citation:
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PMID: 17483244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Perturbation of coronary blood flow (CF) is an important contributor to myocardium-related complications. The study was primarily designed to assess the impact of cardiopulmonary bypass (CPB) surgery on CF by aid of transthoracic Doppler echocardiography. Changes in CF after off-pump coarctation surgery were also studied. All ultrasounds were performed before and 5 +/- 1 days after surgery. Eighteen children underwent CPB surgery of ventricular left-to-right shunts at the mean age of 6 mo, while off-pump surgery (aortic coarctectomy) was undertaken at the mean age of 10 days in 12 children. After CPB surgery, both left anterior descending coronary artery mean diameter and basal CF increased from 1.7 +/- 0.3 to 2.1 +/- 0.4 mm (P = 0.001) and 27 +/- 10 to 47 +/- 15 ml/min (P = 0.0001), respectively. These two coronary variables decreased after off-pump coarctectomy: left anterior descending coronary artery mean diameter from 1.8 +/- 0.1 to 1.7 +/- 0.1 mm (P = 0.06), and CF from 44 +/- 12 to 25 +/- 8 ml/min (P = 0.001). The findings are in keeping with the hypothesis that the previously reported impairment of coronary flow reserve after CPB surgery could be due to increase in basal coronary flow after CPB. Off-pump coarctectomy seems to have little impact on CF, as the postsurgical decline in flow in these patients seems to relate to the reduction in cardiac pressure afterload. |
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Authors:
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Elhadi H Aburawi; Ansgar Berg; Petru Liuba; Erkki Pesonen |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-05-04 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 293 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-03 Completed Date: 2007-09-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1138-43 Citation Subset: IM |
Affiliation:
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Division of Pediatric Cardiology/Department of Pediatrics, Lund University Hospital, Getingvägen, SE-221 85 Lund, Sweden. elhadi.aburawi@med.lu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aortic Coarctation
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physiopathology,
surgery,
ultrasonography* Cardiac Surgical Procedures* Cardiopulmonary Bypass* Case-Control Studies Coronary Circulation* Coronary Vessels / physiopathology, surgery, ultrasonography* Echocardiography, Doppler* Heart Septal Defects, Atrial / physiopathology, surgery, ultrasonography* Heart Septal Defects, Ventricular / physiopathology, surgery, ultrasonography* Humans Infant Infant, Newborn Observer Variation Reproducibility of Results Research Design Treatment Outcome Ventricular Function, Left |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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