| Effects of cardiac resynchronization therapy on coronary blood flow: evaluation by transthoracic Doppler echocardiography. | |
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MedLine Citation:
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PMID: 18436475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Relatively limited and conflicting data are available on the effects of cardiac resynchronization therapy (CRT) on coronary blood flow (CBF). AIMS: To investigate changes in the left anterior descending coronary artery (LAD) flow under different CRT pacing modes by means of transthoracic Doppler echocardiography (TTE). METHODS: Twenty-two responders to CRT (67+/-11 years) with idiopathic dilated cardiomyopathy underwent TTE assessment of LAD flow and Tissue Velocity Imaging during 4 programming modes: intrinsic conduction (IC), right ventricular pacing (RV), simultaneous biventricular pacing (BVP), BVP with left ventricular (LV) pre-activation. RESULTS: Mean coronary flow velocity (CFV) was increased by simultaneous BVP (p=0.0063 vs. IC) and BVP with LV pre-activation (p<0.0001 vs. IC; p=0.027 vs. simultaneous BVP). Peak CFV and LAD flow velocity/time integral were highest during BVP with LV pre-activation. A reduction in septal-to-lateral delay and an increase in peak systolic velocity in the basal septum were observed during simultaneous BVP and BVP with LV pre-activation. CONCLUSIONS: In CRT responders with idiopathic dilated cardiomyopathy, an increase in LAD flow, assessed by TTE, was observed during simultaneous BVP and BVP with LV pre-activation. This was associated with an improvement in regional myocardial contraction and a decrease in intraventricular dyssynchrony. |
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Authors:
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Cinzia Valzania; Fredrik Gadler; Reidar Winter; Frieder Braunschweig; Lars-Ake Brodin; Petri Gudmundsson; Giuseppe Boriani; Maria J Eriksson |
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Publication Detail:
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Type: Journal Article Date: 2008-04-24 |
Journal Detail:
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Title: European journal of heart failure Volume: 10 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-05 Completed Date: 2008-09-30 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 514-20 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Cardiology, Karolinska Institutet, Stockholm, Sweden. cinzia.valzania2@studio.unibo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Flow Velocity Cardiac Pacing, Artificial* Cardiomyopathy, Dilated / complications, therapy* Coronary Circulation* Echocardiography Echocardiography, Doppler* Female Humans Male Middle Aged Myocardial Contraction Ventricular Dysfunction, Left / etiology, therapy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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