Document Detail


Effects of cardiac glycosides on myocardial function and energetics in conscious dogs.
MedLine Citation:
PMID:  7977836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The physiological effects of intravenous ouabain on left ventricular (LV) systolic function and metabolic-to-mechanical energy transfer were examined in eight conscious dogs. LV pressure and volume were measured using micromanometers and ultrasonic dimension transducers during transient vena caval occlusions under control conditions and after increasing doses of ouabain. Doppler coronary flow and coronary sinus O2 saturations were used to determine arterial-to-coronary sinus O2 content difference and thereby to calculate LV O2 consumption; total mechanical energy was computed as the sum of LV stroke work and the product of end-diastolic volume and LV mean ejection pressure, neglecting LV unstressed cavitary volume. The slope (10(4) erg/ml) of the stroke work vs. end-diastolic volume relationship increased progressively with rising doses of ouabain from 7.0 +/- 1.6 at control to 9.6 +/- 1.7 after ouabain 0.75 mg (P = 0.0002). Regression analysis of LV O2 consumption (mW/cm3) vs. total mechanical energy (mW/cm3) yielded a linear relationship that did not change with 0.75 mg of ouabain (P > 0.4). These data indicate that ouabain possesses a significant positive inotropic effect on the intact left ventricle without a change in energy transfer efficiency or O2 wasting.
Authors:
J C Lucke; J R Elbeery; T C Koutlas; S A Gall; T A D'Amico; G W Maier; J S Rankin; D D Glower
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  267     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1994-12-08     Completed Date:  1994-12-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H2042-9     Citation Subset:  IM    
Affiliation:
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710.
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MeSH Terms
Descriptor/Qualifier:
Animals
Consciousness
Diastole / drug effects
Dogs
Dose-Response Relationship, Drug
Energy Metabolism / drug effects
Heart / drug effects,  physiology*
Myocardium / metabolism*
Ouabain / pharmacology*
Oxygen / blood
Oxygen Consumption / drug effects*
Regression Analysis
Stroke Volume / drug effects
Ventricular Function, Left / drug effects,  physiology
Grant Support
ID/Acronym/Agency:
HL-17670/HL/NHLBI NIH HHS; HL-29436/HL/NHLBI NIH HHS; HL-46242/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
630-60-4/Ouabain; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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