Document Detail

Effects of cardiac glycosides on 24-h ambulatory blood pressure in healthy volunteers and patients with heart failure.
MedLine Citation:
PMID:  11525235     Owner:  NLM     Status:  MEDLINE    
Blood pressure effects of cardiac glycosides in humans have been infrequently reported. Although direct infusion of ouabain or digoxin causes vasoconstriction, indirect effects of cardiac glycosides may have the opposite effect, owing to changes in sympatho-vagal balance. This paper summarises three studies on the effects of cardiac glycosides on circadian blood pressure, utilizing automatic 24-h ambulatory blood pressure measurement (ABPM). In healthy volunteers, 10 days of oral digoxin or digitoxin caused decreases in diastolic blood pressure and heart rate during overnight sleep. No effect was detectable during daytime activities. In patients with heart failure (NYHA stage II), 7 days of oral digoxin also caused a decrease in diastolic blood pressure but only a small increase in systolic pressure during overnight sleep. Again, no effect was detectable during the day. Cardiac glycosides have significant effects on blood pressure, which only appear during overnight sleep, i.e. a phase when sympathetic background activity is lowest. Regular daytime activities may 'overwrite' these effects. Effects of cardiac glycosides on blood pressure may have therapeutic impact, depending on the stage of heart failure and concomitant diseases.
M Grossmann
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  31 Suppl 2     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  2001  
Date Detail:
Created Date:  2001-08-29     Completed Date:  2001-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  26-30     Citation Subset:  IM    
Institute of Clinical Pharmacology, Faculty of Medicine, University of Technology, Dresden, Germany.
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MeSH Terms
Blood Pressure / drug effects*
Blood Pressure Monitoring, Ambulatory
Cardiac Glycosides / administration & dosage*
Cardiotonic Agents / administration & dosage*
Heart Failure / drug therapy*
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Cardiac Glycosides; 0/Cardiotonic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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