| Effects of carboxymethyl chitosan on the blood system of rats. | |
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MedLine Citation:
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PMID: 21463605 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Carboxymethyl chitosan (CM-chitosan), a derivative of chitosan, was extensively studied in the biomedical materials field for its beneficial biological properties of hemostasis and stimulation of healing. However, studies examining the safety of CM-chitosan in the blood system are lacking. In this study CM-chitosan was implanted into the abdominal cavity of rats to determine blood indexes at different times and to evaluate the effects of CM-chitosan on the blood system of rats. Coagulation function was reflected by thrombin time (TT), prothrombin time (PT), activated partial thromboplatin time (APTT), fibrinogen (FIB) and platelet factor 4 (PF4) indexes; Anti-coagulation performance was assessed by the index of antithrombinIII (ATIII); Fibrinolytic function was reflected by plasminogen (PLG) and fibrin degradation product (FDP) indexes; And blood viscosity (BV) and plasma viscosity (PV) indexes reflected hemorheology. Results showed that CM-chitosan has no significant effects on the blood system of rats, and provides experimental basis for CM-chitosan to be applied in the field of biomedical materials. |
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Authors:
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Dawei Fu; Baoqin Han; Wen Dong; Zhao Yang; You Lv; Wanshun Liu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-1 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: - ISSN: 1090-2104 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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College of Marine Life Sciences, Ocean University of China, Qingdao 266003,People's Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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