Document Detail


Effects of the carbonic anhydrase inhibitor acetazolamide on splanchnic blood flow in anaesthetized rats.
MedLine Citation:
PMID:  9934821     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to evaluate whether inhibition of the enzyme carbonic anhydrase with acetazolamide interfered with pancreatic islet and whole splanchnic blood perfusion in rats. Carbonic anhydrase is present both in the endocrine cells and, in particular, the endothelium of the pancreatic islet. Thiobutabarbital-anaesthetized, male Sprague-Dawley rats were used in all experiments, and acetazolamide (50 mg/kg body weight) was given to untreated control rats or rats pretreated with glucose, i.e. to normoglycaemic and hyperglycaemic animals. No acetazolamide-induced effects on blood glucose or serum insulin concentrations, mean arterial blood pressure, whole pancreatic or islet blood flow were seen in any of the animals. There were no effects on duodenal or colonic blood flow recorded in the control rats, whereas an increase in duodenal blood flow (P<0.02) was observed in the hyperglycaemic animals. A tendency to an increase was seen in colonic blood flow in hyperglycaemic animals, although this was not statistically significant (P = 0.069). Inhibition of carbonic anhydrase seems to induce only minor effects on pancreatic blood flow, while duodenal blood flow is slightly enhanced in hyperglycaemic animals.
Authors:
P O Carlsson; M Lindberg; L Jansson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta diabetologica     Volume:  35     ISSN:  0940-5429     ISO Abbreviation:  Acta Diabetol     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-04-13     Completed Date:  1999-04-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9200299     Medline TA:  Acta Diabetol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  215-9     Citation Subset:  IM    
Affiliation:
Department of Medical Cell Biology, Biomedical Centre, Uppsala, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Acetazolamide / pharmacology*
Animals
Blood Glucose / analysis
Carbonic Anhydrase Inhibitors / pharmacology*
Colon / blood supply
Duodenum / blood supply
Hyperglycemia / physiopathology
Insulin / blood
Islets of Langerhans / blood supply
Male
Pancreas / blood supply
Rats
Rats, Sprague-Dawley
Reference Values
Splanchnic Circulation / drug effects*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Carbonic Anhydrase Inhibitors; 11061-68-0/Insulin; 59-66-5/Acetazolamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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