| Effects of the carbonic anhydrase inhibitor acetazolamide on splanchnic blood flow in anaesthetized rats. | |
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MedLine Citation:
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PMID: 9934821 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to evaluate whether inhibition of the enzyme carbonic anhydrase with acetazolamide interfered with pancreatic islet and whole splanchnic blood perfusion in rats. Carbonic anhydrase is present both in the endocrine cells and, in particular, the endothelium of the pancreatic islet. Thiobutabarbital-anaesthetized, male Sprague-Dawley rats were used in all experiments, and acetazolamide (50 mg/kg body weight) was given to untreated control rats or rats pretreated with glucose, i.e. to normoglycaemic and hyperglycaemic animals. No acetazolamide-induced effects on blood glucose or serum insulin concentrations, mean arterial blood pressure, whole pancreatic or islet blood flow were seen in any of the animals. There were no effects on duodenal or colonic blood flow recorded in the control rats, whereas an increase in duodenal blood flow (P<0.02) was observed in the hyperglycaemic animals. A tendency to an increase was seen in colonic blood flow in hyperglycaemic animals, although this was not statistically significant (P = 0.069). Inhibition of carbonic anhydrase seems to induce only minor effects on pancreatic blood flow, while duodenal blood flow is slightly enhanced in hyperglycaemic animals. |
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Authors:
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P O Carlsson; M Lindberg; L Jansson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta diabetologica Volume: 35 ISSN: 0940-5429 ISO Abbreviation: Acta Diabetol Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-04-13 Completed Date: 1999-04-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9200299 Medline TA: Acta Diabetol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 215-9 Citation Subset: IM |
Affiliation:
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Department of Medical Cell Biology, Biomedical Centre, Uppsala, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetazolamide
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pharmacology* Animals Blood Glucose / analysis Carbonic Anhydrase Inhibitors / pharmacology* Colon / blood supply Duodenum / blood supply Hyperglycemia / physiopathology Insulin / blood Islets of Langerhans / blood supply Male Pancreas / blood supply Rats Rats, Sprague-Dawley Reference Values Splanchnic Circulation / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Carbonic Anhydrase Inhibitors; 11061-68-0/Insulin; 59-66-5/Acetazolamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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