Document Detail

Effects of carbon dioxide insufflation combined with changes in body position on blood gas and acid-base status in anesthetized llamas (Llama glama).
MedLine Citation:
PMID:  9381667     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the combined effects of intra-abdominal CO2 insufflation with changes in body position during laparoscopy in xylazine-ketamine-halothane anesthetized llamas.
STUDY DESIGN: Prospective, controlled study.
ANIMALS: Nine castrated, male llamas weighing 114 +/- 23 kg, 3 to 13 years old.
METHODS: Three llamas (preliminary study [PS] group) were used to study the effect of right, lateral, dorsal, and left lateral recumbency on gas exchange and acid-base status. The other six (experimental study [ES] group) were used to study the combined effects of changes in body position and CO2 insufflation to an intraabdominal pressure of 10 to 12 mm Hg. Heart rate, respiratory rate, and indirect arterial blood pressures (systolic [SAP], mean [MAP], and diastolic [DAP]) were recorded every 5 minutes during anesthesia. Arterial blood gases (PaO2 and PaCO2) and acid-base status (pHa and HCO3-) were measured immediately after induction of anesthesia and before each change of position.
RESULTS: In the PS group, significant decreases in SAP, MAP and PaCO2 and increases in PaO2 and pHa were observed when the llamas were turned from right lateral to dorsal recumbency. Values for HCO3- were lower than the postinduction values, but they remained unaffected by the changes in position. In the ES group, values for MAP were significantly lower when the llamas were placed in dorsal and left lateral recumbency than those observed during right lateral recumbency. Arterial O2 tension during right lateral recumbency was lower but returned to preinsufflation values when the llamas were placed in the dorsal position. All llamas recovered uneventfully within 30 minutes after termination of anesthesia.
CONCLUSIONS: Insufflation of CO2 and changing body position induce minor and transient changes in cardiovascular and respiratory function.
CLINICAL RELEVANCE: Laparoscopy with mild intra-abdominal CO2 insufflation (10 to 12 mm Hg) can be used safely in spontaneously breathing llamas anesthetized with xylazine, ketamine, and halothane.
H C Lin; A N Baird; D G Pugh; D E Anderson; E M Gaughan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary surgery : VS     Volume:  26     ISSN:  0161-3499     ISO Abbreviation:  Vet Surg     Publication Date:    1997 Sep-Oct
Date Detail:
Created Date:  1997-11-07     Completed Date:  1997-11-07     Revised Date:  2011-04-25    
Medline Journal Info:
Nlm Unique ID:  8113214     Medline TA:  Vet Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  444-50     Citation Subset:  IM    
Department of Large Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, AL 36849-5522, USA.
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MeSH Terms
Acid-Base Equilibrium / drug effects,  physiology*
Anesthesia / methods,  veterinary
Anesthetics / pharmacology
Anesthetics, Dissociative / pharmacology
Anesthetics, Inhalation / pharmacology
Bicarbonates / blood
Blood Gas Analysis / methods,  veterinary
Blood Pressure / drug effects,  physiology
Camelids, New World / blood,  physiology*
Carbon Dioxide / administration & dosage,  blood*,  pharmacology*
Halothane / pharmacology
Heart Rate / drug effects,  physiology
Hydrogen-Ion Concentration
Insufflation / methods,  veterinary*
Ketamine / pharmacology
Laparoscopy / methods,  veterinary
Oxygen / blood*
Posture / physiology*
Prospective Studies
Pulmonary Ventilation / physiology
Respiration / drug effects,  physiology
Unconsciousness / blood,  physiopathology,  veterinary*
Xylazine / pharmacology
Reg. No./Substance:
0/Anesthetics; 0/Anesthetics, Dissociative; 0/Anesthetics, Inhalation; 0/Bicarbonates; 124-38-9/Carbon Dioxide; 151-67-7/Halothane; 6740-88-1/Ketamine; 7361-61-7/Xylazine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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