Document Detail


Effects of carbamazepine and anti-depressant drugs on endogenous catecholamine levels in the cerebroventricular compartment of the rat.
MedLine Citation:
PMID:  6431468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Concentrations of endogenous norepinephrine, dopamine and epinephrine in cerebroventricular perfusates were used to evaluate the effects of drugs on the availability of extracellular catecholamines in the intact rat brain. Administration of the antidepressant drugs imipramine, desmethylimipramine or tranylcypromine resulted in marked increases of both norepinephrine and dopamine concentrations while epinephrine levels were not affected. Treatment with a similar dose of carbamazepine - an anticonvulsant drug with antidepressant activity - resulted in a significant increase in dopamine concentrations without apparent effect on either norepinephrine or epinephrine. It is suggested that at the applied dose, carbamazepine may act to modify the uptake, release or metabolism of dopamine in brain areas adjacent to the cerebroventricular space without affecting the other catecholamines.
Authors:
S Kowalik; M Levitt; A I Barkai
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychopharmacology     Volume:  83     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1984  
Date Detail:
Created Date:  1984-09-20     Completed Date:  1984-09-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  169-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antidepressive Agents / pharmacology*
Brain / metabolism
Carbamazepine / pharmacology*
Catecholamines / analysis*
Cerebral Ventricles / analysis*
Dopamine / metabolism
Male
Perfusion
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
MH33690/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Antidepressive Agents; 0/Catecholamines; 298-46-4/Carbamazepine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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