Document Detail

Effects of captopril on pulmonary haemodynamics.
MedLine Citation:
PMID:  6386489     Owner:  NLM     Status:  MEDLINE    
The effects of oral captopril on pulmonary haemodynamics were studied in two groups of 6 patients, one of subjects with chronic respiratory failure (PaO2 52 +/- 5.1 mmHg, PaCO2 54 +/- 2.1 mmHg), and the others with chronic heart failure and high plasma renin activity. Two potential mechanisms of its actions were assessed, namely inhibition of hypoxic vasoconstriction and inhibition of the possible effects of angiotensin II on the pulmonary circulation. There were significant (p less than 0.05) decreases in mean arterial pressure, pulmonary wedge pressure and in systemic arterial resistance associated with improvement in cardiac index in both groups. In the chronic respiratory failure group there was no change in blood gases, mean pulmonary arterial pressure or pulmonary vascular resistance. An increase in driving pressure (p less than 0.05) indicated that captopril had had no effect on pulmonary haemodynamics. In chronic heart failure, mean pulmonary arterial pressure and pulmonary capillary wedge pressure were decreased by a similar extent, so that driving pressure and pulmonary vascular resistance were not changed. It is concluded that oral captopril did not inhibit hypoxic vasoconstriction, and that it modified pulmonary haemodynamics in chronic heart failure patients with high renin activity only as a consequence of reduction in systemic afterload.
C Richard; J L Ricome; A Rimailho; M Conrad; P Auzépy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  27     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1984  
Date Detail:
Created Date:  1984-12-20     Completed Date:  1984-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  35-9     Citation Subset:  IM    
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MeSH Terms
Aldosterone / blood
Blood Pressure / drug effects
Captopril / pharmacology*
Cardiac Output / drug effects
Coronary Disease / physiopathology
Heart Rate / drug effects
Middle Aged
Myocardium / metabolism
Oxygen / blood
Oxygen Consumption / drug effects
Proline / analogs & derivatives*
Pulmonary Circulation / drug effects*
Respiratory Insufficiency / physiopathology
Vascular Resistance / drug effects
Reg. No./Substance:
147-85-3/Proline; 52-39-1/Aldosterone; 62571-86-2/Captopril; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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