Document Detail


Effects of captopril on neurosecretion and vascular responsiveness in hypertension.
MedLine Citation:
PMID:  3038398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of the present study was to investigate the mechanisms of hypotensive action of an angiotensin converting enzyme inhibitor (captopril) in hypertension. In perfused mesenteric vasculatures from spontaneously hypertensive rats (SHR) and normotensive Wistar kyoto rats (WKY), the effects of captopril on the vascular responsiveness and norepinephrine overflow from the adrenergic nerve endings were examined. The vasoconstrictor responses and norepinephrine overflow during the electrical nerve stimulation was significantly enhanced in SHR compared with WKY. Captopril reduced not only vasoconstrictor responses but also norepinephrine overflow during the nerve stimulation in a dose-dependent fashion. The suppressions of these responses by captopril were significantly greater in SHR than in WKY. These results demonstrate that captopril could affect the presynaptic site of the resistance vessels and cause a decrease in electrically-stimulated norepinephrine overflow from the adrenergic nerve endings. The marked reduction of the pressor responses and norepinephrine overflow to nerve stimulation by captopril in the SHR suggests that the renin-angiotensin system in the vascular beds in enhanced in this model of hypertension.
Authors:
K Tsuda; H Shima; M Kuchii; I Nishio; Y Masuyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  9     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1987  
Date Detail:
Created Date:  1987-08-28     Completed Date:  1987-08-28     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  375-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Captopril / pharmacology*
Electric Stimulation
Hemodynamics / drug effects*
Hypertension / physiopathology*
Neurosecretion / drug effects*
Norepinephrine / metabolism
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Splanchnic Circulation / drug effects
Sympathetic Nervous System / drug effects
Synaptic Transmission / drug effects
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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