| Effects of capsaicin on the sensorimotor function of the proximal stomach in humans. | |
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MedLine Citation:
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PMID: 14871281 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Capsaicin-sensitive afferents have been implicated in the control of visceral sensorimotor functions. AIM: To study the effects of capsaicin on the sensorimotor function of the proximal stomach in humans. METHODS: In 10 healthy subjects, a gastric barostat was used to study the effect of saline or capsaicin-containing red pepper sauce on the sensitivity to gastric distension and on gastric accommodation to a meal. RESULTS: The administration of capsaicin was accompanied by a relaxation of the proximal stomach. After capsaicin, the compliance of the proximal stomach was increased and higher perception scores were reached for the same distending pressures. Dosing with capsaicin significantly decreased the pressures and corresponding wall tensions at the discomfort threshold. Gastric accommodation to a meal was not altered by capsaicin. CONCLUSION: The acute administration of capsaicin decreases proximal gastric tone, inhibits phasic contractility of the proximal stomach and increases sensitivity to proximal gastric distension. These data suggest the involvement of vanilloid receptor 1 in the modulation of gastric sensorimotor function in humans. |
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Authors:
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K-J Lee; R Vos; J Tack |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 19 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-02-11 Completed Date: 2004-04-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 415-25 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Afferent Pathways / drug effects* Capsaicin / pharmacology* Female Humans Male Muscle Contraction / drug effects Postprandial Period / drug effects Pressure Sensation / drug effects Sensory Thresholds Stomach / drug effects* |
| Chemical | |
Reg. No./Substance:
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404-86-4/Capsaicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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