Document Detail

Effects of capsaicin on the sensorimotor function of the proximal stomach in humans.
MedLine Citation:
PMID:  14871281     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Capsaicin-sensitive afferents have been implicated in the control of visceral sensorimotor functions. AIM: To study the effects of capsaicin on the sensorimotor function of the proximal stomach in humans. METHODS: In 10 healthy subjects, a gastric barostat was used to study the effect of saline or capsaicin-containing red pepper sauce on the sensitivity to gastric distension and on gastric accommodation to a meal. RESULTS: The administration of capsaicin was accompanied by a relaxation of the proximal stomach. After capsaicin, the compliance of the proximal stomach was increased and higher perception scores were reached for the same distending pressures. Dosing with capsaicin significantly decreased the pressures and corresponding wall tensions at the discomfort threshold. Gastric accommodation to a meal was not altered by capsaicin. CONCLUSION: The acute administration of capsaicin decreases proximal gastric tone, inhibits phasic contractility of the proximal stomach and increases sensitivity to proximal gastric distension. These data suggest the involvement of vanilloid receptor 1 in the modulation of gastric sensorimotor function in humans.
K-J Lee; R Vos; J Tack
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  19     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-11     Completed Date:  2004-04-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  415-25     Citation Subset:  IM    
Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium.
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MeSH Terms
Afferent Pathways / drug effects*
Capsaicin / pharmacology*
Muscle Contraction / drug effects
Postprandial Period / drug effects
Sensation / drug effects
Sensory Thresholds
Stomach / drug effects*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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