Document Detail

Effects of cannabis on cognitive function in patients with multiple sclerosis.
MedLine Citation:
PMID:  21444900     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: While neuropsychological deficits have been reported in healthy individuals who use street cannabis, data in patients with multiple sclerosis (MS) are lacking. Given that MS is associated with cognitive deterioration, the aim of this study was to determine the neuropsychological effects of cannabis use in this population.
METHODS: Two groups, each of 25 patients with MS (cannabis users and nonusers), were administered the Minimal Assessment of Cognitive Function in MS battery of neuropsychological tests, the Hospital Anxiety and Depression Scale (HADS), and the Structured Clinical Interview for the DSM-IV Axis I Disorders (SCID-I). Group-matching and regression analysis were used to control for the effects of age, sex, education, premorbid intelligence, disability, and disease course and duration on cognitive function.
RESULTS: Cannabis users performed significantly more poorly than nonusers on measures of information processing speed, working memory, executive functions, and visuospatial perception. They were also twice as likely as nonusers to be classified as globally cognitively impaired. There were no between-group differences on the HADS measures of depression and anxiety or lifetime SCID-I psychiatric diagnoses.
CONCLUSION: This cross-sectional study provides empirical evidence that prolonged use of inhaled or ingested street cannabis in patients with MS is associated with poorer performance on cognitive domains commonly affected in this population. Whatever subjective benefits patients may derive from using street cannabis (e.g., pain and spasticity relief) should be weighed against the associated cognitive side effects.
Kimia Honarmand; Mary C Tierney; Paul O'Connor; Anthony Feinstein
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  76     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-29     Completed Date:  2011-05-20     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1153-60     Citation Subset:  AIM; IM    
University of Toronto, 27 King's College Circle, Toronto, Ontario, Canada M5S.
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MeSH Terms
Cognition / drug effects*,  physiology
Cognition Disorders / etiology*
Cross-Sectional Studies
Middle Aged
Multiple Sclerosis / complications*,  drug therapy*
Neuropsychological Tests
Plant Preparations / pharmacology,  therapeutic use*
Prospective Studies
Psychiatric Status Rating Scales
Young Adult
Reg. No./Substance:
0/Plant Preparations
Comment In:
J Neurol. 2011 May;258(5):954-7   [PMID:  21512740 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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