| Effects of a cannabinoid receptor agonist on colonic motor and sensory functions in humans: a randomized, placebo-controlled study. | |
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MedLine Citation:
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PMID: 17395895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cannabinoid receptors (CBR) are located on cholinergic neurons in the brain stem, stomach, and colon. CBR stimulation inhibits motility in rodents. Effects in humans are unclear. Dronabinol (DRO), a nonselective CBR agonist, inhibits colonic motility and sensation. The aim of this study was to compare effects of DRO and placebo (PLA) on colonic motility and sensation in healthy volunteers. Fifty-two volunteers were randomly assigned (double-blind) to a single dose of 7.5 mg DRO or PLA postoperative with concealed allocation. A balloon-manometric assembly placed into the descending colon allowed assessment of colonic compliance, motility, tone, and sensation before and 1 h after oral ingestion of medication, and during fasting, and for 1 h after 1,000-kcal meal. There was an overall significant increase in colonic compliance (P = 0.045), a borderline effect of relaxation in fasting colonic tone (P = 0.096), inhibition of postprandial colonic tone (P = 0.048), and inhibition of fasting and postprandial phasic pressure (P = 0.008 and 0.030, respectively). While DRO did not significantly alter thresholds for first gas or pain sensation, there was an increase in sensory rating for pain during random phasic distensions at all pressures tested and in both genders (P = 0.024). In conclusion, in humans the nonselective CBR agonist, DRO, relaxes the colon and reduces postprandial colonic motility and tone. Increase in sensation ratings to distension in the presence of relaxation of the colon suggests central modulation of perception. The potential for CBR to modulate colonic motor function in diarrheal disease such as irritable bowel syndrome deserves further study. |
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Authors:
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Tuba Esfandyari; Michael Camilleri; Irene Busciglio; Duane Burton; Kari Baxter; Alan R Zinsmeister |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2007-03-29 |
Journal Detail:
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Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 293 ISSN: 0193-1857 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-06 Completed Date: 2007-09-12 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
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Languages: eng Pagination: G137-45 Citation Subset: IM |
Affiliation:
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Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Colon / drug effects*, innervation, physiology* Compliance / drug effects Fasting Female Gastrointestinal Transit / drug effects* Humans Male Pain Receptors, Cannabinoid / agonists* Sensory Thresholds / drug effects Tetrahydrocannabinol / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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K24 DK 02638/DK/NIDDK NIH HHS; R01 DK 54681/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Cannabinoid; 1972-08-3/Tetrahydrocannabinol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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