| Effects of canine parvovirus strain variations on diagnostic test results and clinical management of enteritis in dogs. | |
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MedLine Citation:
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PMID: 22720989 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective-To estimate the prevalence of canine parvovirus (CPV) strains among dogs with enteritis admitted to a referral hospital in the southwestern United States during an 11-month period and to compare diagnostic test results, disease severity, and patient outcome among CPV strains. Design-Prospective observational study. Animals-72 dogs with histories and clinical signs of parvoviral enteritis. Procedures-For each dog, a fecal sample or rectal swab specimen was evaluated for CPV antigen via an ELISA. Subsequently, fecal samples (n = 42 dogs) and pharyngeal swab specimens (16) were obtained and tested for CPV antigen via an ELISA and CPV DNA via a PCR assay. For specimens with CPV-positive results via PCR assay, genetic sequencing was performed to identify the CPV strain. Results-56 dogs tested positive for CPV via ELISA or PCR assay. For 42 fecal samples tested via both ELISA and PCR assay, 27 had positive results via both assays, whereas 6 had positive PCR assay results only. Ten pharyngeal swab specimens yielded positive PCR assay results. Genetic sequencing was performed on 34 fecal or pharyngeal swab specimens that had CPV-positive PCR assay results; 25 (73.5%) were identified as containing CPV type-2c, and 9 (26.5%) were identified as containing CPV type-2b. No association was found between CPV strain and disease severity or clinical outcome. Conclusions and Clinical Relevance-CPV type-2b and CPV type-2c posed similar health risks for dogs; therefore, genetic sequencing of CPV does not appear necessary for clinical management of infected patients. The diagnostic tests used could detect CPV type-2c. |
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Authors:
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Jessica E Markovich; Karla M Stucker; Alaina H Carr; Carole E Harbison; Janet M Scarlett; Colin R Parrish |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Veterinary Medical Association Volume: 241 ISSN: 1943-569X ISO Abbreviation: J. Am. Vet. Med. Assoc. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-06-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503067 Medline TA: J Am Vet Med Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 66-72 Citation Subset: IM |
Affiliation:
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VCA Animal Referral and Emergency Center of Arizona, 1648 N Country Club Dr, Mesa, AZ 85201. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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