Document Detail

Effects of the calcium ionophore A 23187 on low-density lipoprotein processing and lipid metabolism in cultured human fibroblasts.
MedLine Citation:
PMID:  6437867     Owner:  NLM     Status:  MEDLINE    
Pretreatment of cultured human fibroblasts with the calcium ionophore A 23187 resulted in a decrease in low-density lipoprotein internalization. This effect was dose-dependent and did not occur in a medium devoid of calcium. About 2-fold reduction was observed with 10(-5)M A 23187. In contrast, the low-density lipoprotein binding was only slightly affected. The incorporation of [14C]acetate and [14C]oleate into all classes of lipids (sterol, triacylglycerols and phospholipids) was strikingly reduced by ionophore pretreatment.
J C Mazière; C Mazière; L Mora; J Gardette; J Polonovski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEBS letters     Volume:  177     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1985-01-03     Completed Date:  1985-01-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  76-80     Citation Subset:  IM    
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MeSH Terms
Acetic Acid
Acetic Acids / metabolism
Calcimycin / pharmacology*
Calcium / pharmacology
Cells, Cultured
Dose-Response Relationship, Drug
Fibroblasts / drug effects,  metabolism*
Lipoproteins, LDL / metabolism*
Lung / metabolism
Oleic Acid
Oleic Acids / metabolism
Reg. No./Substance:
0/Acetic Acids; 0/Lipoproteins, LDL; 0/Oleic Acids; 112-80-1/Oleic Acid; 52665-69-7/Calcimycin; 64-19-7/Acetic Acid; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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