| Effects of calcium chloride on grafted internal mammary artery flow after cardiopulmonary bypass. | |
| | |
MedLine Citation:
|
PMID: 10698383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To examine the effects of calcium chloride (CaCl2) administration on blood flow through the grafted left internal mammary artery (IMA) after cardiopulmonary bypass (CPB). DESIGN: Single-arm prospective study. SETTING: University-affiliated hospital operating room. PARTICIPANTS: Twenty adult patients scheduled for coronary artery bypass graft surgery with IMA graft. INTERVENTIONS: IMA flow was measured noninvasively with a laser Doppler flow probe placed around the IMA, and measurements were recorded for 10 seconds and averaged. After separation from CPB under stable hemodynamics, baseline IMA flow was measured. CaCl2, 15 mg/kg, was administered intravenously over 1 minute. Blood pressure, left atrial pressure, heart rate, and IMA flow were then measured at 1, 5, and 10 minutes. Coronary perfusion pressure and IMA vascular resistance were calculated. MEASUREMENTS AND MAIN RESULTS: After CaCl2 administration, IMA blood flow significantly decreased from baseline at 1, 5, and 10 minutes (from 28+/-9 mL/min to 19+/-8 mL/min, 22+/-6 mL/min, and 25+/-4 mL/min), with gradual return toward baseline over time. Blood pressure, coronary perfusion pressure, and IMA vascular resistance significantly increased at 1 and 5 minutes after CaCl2. Left atrial pressure and heart rate remained unchanged. No systolic regional wall motion abnormalities were detected on transesophageal echocardiography. CONCLUSIONS: CaCl2, administered as a bolus dose after separation from CPB, transiently but significantly reduces IMA flow and can potentially trigger vasospasm, increasing the risk for myocardial ischemia or infarction in susceptible patients. Further studies are needed to determine whether this effect also occurs with nitrosodilators or phosphodiesterase inhibitors. |
| | |
Authors:
|
G M Janelle; F Urdaneta; T D Martin; E B Lobato |
Related Documents
:
|
3252043 - Coronary thrombolysis with intravenous streptokinase in the anesthetized dog: a dose-re... 7468243 - The role of coronary perfusion pressure in the control of mechanical performance and ox... 12736013 - Urodynamic effects of intravesical nociceptin/orphanin fq in neurogenic detrusor overac... |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: Journal of cardiothoracic and vascular anesthesia Volume: 14 ISSN: 1053-0770 ISO Abbreviation: J. Cardiothorac. Vasc. Anesth. Publication Date: 2000 Feb |
Date Detail:
|
Created Date: 2000-03-16 Completed Date: 2000-03-16 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9110208 Medline TA: J Cardiothorac Vasc Anesth Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 4-8 Citation Subset: IM |
Affiliation:
|
Department of Anesthesiology, University of Florida College of Medicine, Gainesville, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Blood Flow Velocity / drug effects Blood Pressure / drug effects Calcium Chloride / administration & dosage, adverse effects* Cardiopulmonary Bypass* Coronary Artery Bypass* Coronary Circulation / drug effects Female Heart Rate / drug effects Humans Laser-Doppler Flowmetry Male Mammary Arteries / drug effects*, physiology, transplantation Prospective Studies Vascular Resistance / drug effects Vasoconstriction / drug effects |
| Chemical | |
Reg. No./Substance:
|
10043-52-4/Calcium Chloride |
| Comments/Corrections | |
Comment In:
|
J Cardiothorac Vasc Anesth. 2000 Feb;14(1):1-3
[PMID:
10698382
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adolescents are not adults: developmental considerations in alcohol users.
Next Document: Effects of milrinone versus epinephrine on grafted internal mammary artery flow after cardiopulmonar...