Document Detail

Effects of the calcium antagonist, diltiazem on in vitro and in vivo/in vitro bone resorption.
MedLine Citation:
PMID:  3838964     Owner:  NLM     Status:  MEDLINE    
The effect of the calcium antagonist diltiazem on bone resorption in organ culture has been investigated. It was found that diltiazem was ineffective alone but that in concentrations above 5 mumol/l it reduced mineral and organic resorption induced in vitro by 1.25 dihydroxycholecalciferol (1.25 (OH)2D3). No additivity with calcitonin effects was observed. Diltiazem did not significantly affect bone resorbing activity stimulated by 24,25(OH)2D3. Bone resorption was measured by an in vivo/in vitro technique using 45Ca prelabelled mice. Compared with 1.25(OH)2D3 alone treated group (0.480 pmol/g), it was found that diltiazem (100 nmol/g) reduced bone resorption without effect on calcium and phosphorus plasmatic concentrations at death. These data suggest that such a calcium antagonist is able to inhibit 1.25-(OH)2D3-increased-bone resorption either in vitro or in vivo/in vitro.
S Y Ly; C Rebut-Bonneton; L Miravet
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  17     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-07-02     Completed Date:  1985-07-02     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  152-5     Citation Subset:  IM    
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MeSH Terms
Benzazepines / pharmacology*
Bone Resorption / drug effects*
Calcitonin / pharmacology
Calcitriol / pharmacology
Calcium / secretion
Diltiazem / pharmacology*
Dose-Response Relationship, Drug
Intestines / metabolism
Reg. No./Substance:
0/Benzazepines; 32222-06-3/Calcitriol; 42399-41-7/Diltiazem; 7440-70-2/Calcium; 9007-12-9/Calcitonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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