| Effects of caffeoylquinic acid derivatives and C-flavonoid from Lychnophora ericoides on in vitro inflammatory mediator production. | |
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MedLine Citation:
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PMID: 20521538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study we aimed at evaluating the effect of the major polar constituents of the medicinal plant Lychnophora ericoides on the production of inflammatory mediators produced by LPS-stimulated U-937 cells. The 6,8-di-C-beta-glucosylapigenin (vicenin-2) presented no effect on tumor necrosis factor (TNF)-alpha production, but inhibited, in a dose-dependent manner, the production of prostaglandin (PG) E2 without altering the expression of cyclooxygenase (COX)-2 protein. 3,5-Dicaffeoylquinic acid and 4,5-dicaffeoylquinic acid, at lower concentrations, had small but significant effects on reducing PGE2 levels; at higher doses these compounds stimulated PGE2 and also TNF-alpha production by the cells. All the caffeoylquinic acid derivatives, in a dose-dependent fashion, were able to inhibit monocyte chemoattractant protein-3 synthesis/release, with 4,5-DCQ being the most potent at the highest tested concentration. These results add important information on the effects of plant natural polyphenols, namely vicenin-2 and caffeoylquinic acid derivatives, on the production of inflammatory mediators by cultured cells. |
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Authors:
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Michel David dos Santos; Guanjie Chen; Maria Camila Almeida; Denis Melo Soares; Glória Emília Petto de Souza; Norberto Peporine Lopes; R Clark Lantz |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Natural product communications Volume: 5 ISSN: 1934-578X ISO Abbreviation: Nat Prod Commun Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-04 Completed Date: 2010-08-20 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101477873 Medline TA: Nat Prod Commun Country: United States |
Other Details:
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Languages: eng Pagination: 733-40 Citation Subset: IM |
Affiliation:
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Department of Physics and Chemistry, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP, 14040-903, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Phytogenic
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chemistry,
isolation & purification,
pharmacology* Asteraceae / chemistry* Blotting, Western Cell Differentiation / drug effects Cell Line, Tumor Cell Proliferation / drug effects Chemokine CCL7 / biosynthesis Dinoprostone / metabolism* Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Flavonoids / chemistry, isolation & purification, pharmacology* Humans Immunoassay Inflammation Mediators / metabolism* Plant Extracts / chemistry, pharmacology* Quinic Acid / analogs & derivatives*, chemistry, isolation & purification, metabolism Tumor Necrosis Factor-alpha / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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P50 AT000474-050001/AT/NCCAM NIH HHS; P50 AT00474/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/4,5-dicaffeoyl quinic acid; 0/Antineoplastic Agents, Phytogenic; 0/Chemokine CCL7; 0/Flavonoids; 0/Inflammation Mediators; 0/Plant Extracts; 0/Tumor Necrosis Factor-alpha; 0/caffeoylquinic acid; 363-24-6/Dinoprostone; 77-95-2/Quinic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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