Document Detail

Effects of caffeoylquinic acid derivatives and C-flavonoid from Lychnophora ericoides on in vitro inflammatory mediator production.
MedLine Citation:
PMID:  20521538     Owner:  NLM     Status:  MEDLINE    
In this study we aimed at evaluating the effect of the major polar constituents of the medicinal plant Lychnophora ericoides on the production of inflammatory mediators produced by LPS-stimulated U-937 cells. The 6,8-di-C-beta-glucosylapigenin (vicenin-2) presented no effect on tumor necrosis factor (TNF)-alpha production, but inhibited, in a dose-dependent manner, the production of prostaglandin (PG) E2 without altering the expression of cyclooxygenase (COX)-2 protein. 3,5-Dicaffeoylquinic acid and 4,5-dicaffeoylquinic acid, at lower concentrations, had small but significant effects on reducing PGE2 levels; at higher doses these compounds stimulated PGE2 and also TNF-alpha production by the cells. All the caffeoylquinic acid derivatives, in a dose-dependent fashion, were able to inhibit monocyte chemoattractant protein-3 synthesis/release, with 4,5-DCQ being the most potent at the highest tested concentration. These results add important information on the effects of plant natural polyphenols, namely vicenin-2 and caffeoylquinic acid derivatives, on the production of inflammatory mediators by cultured cells.
Michel David dos Santos; Guanjie Chen; Maria Camila Almeida; Denis Melo Soares; Glória Emília Petto de Souza; Norberto Peporine Lopes; R Clark Lantz
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Natural product communications     Volume:  5     ISSN:  1934-578X     ISO Abbreviation:  Nat Prod Commun     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-04     Completed Date:  2010-08-20     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  101477873     Medline TA:  Nat Prod Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  733-40     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification,  pharmacology*
Asteraceae / chemistry*
Blotting, Western
Cell Differentiation / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Chemokine CCL7 / biosynthesis
Dinoprostone / metabolism*
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Flavonoids / chemistry,  isolation & purification,  pharmacology*
Inflammation Mediators / metabolism*
Plant Extracts / chemistry,  pharmacology*
Quinic Acid / analogs & derivatives*,  chemistry,  isolation & purification,  metabolism
Tumor Necrosis Factor-alpha / metabolism*
Grant Support
P50 AT000474/AT/NCCAM NIH HHS; P50 AT000474-050001/AT/NCCAM NIH HHS; P50 AT00474/AT/NCCAM NIH HHS
Reg. No./Substance:
0/4,5-dicaffeoyl quinic acid; 0/Antineoplastic Agents, Phytogenic; 0/Chemokine CCL7; 0/Flavonoids; 0/Inflammation Mediators; 0/Plant Extracts; 0/Tumor Necrosis Factor-alpha; 0/caffeoylquinic acid; 058C04BGYI/Quinic Acid; K7Q1JQR04M/Dinoprostone

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