Document Detail

Effects of caffeine and promazine hydrochloride on plasma catecholamines in thoroughbreds at rest and during treadmill exercise.
MedLine Citation:
PMID:  10659325     Owner:  NLM     Status:  MEDLINE    
Our aim was to investigate plasma catecholamine responses to so-called 'doping' drugs and exercise in Thoroughbreds. Plasma adrenaline (Ad) and noradrenaline (NA) were determined after the administration of caffeine and promazine hydrochloride (PRZ) using a high performance liquid chromatographic method. Caffeine or PRZ was administered i.m. to Thoroughbreds and its effects on plasma catecholamines at rest and during exercise were compared with the saline control. The treadmill exercise was performed 1 h after administration. A dose of 5.0 mg/kg bwt caffeine was found to significantly increase both plasma Ad and NA levels but this was not the case for the 2.5 mg/kg bwt dose and their peak levels at 1.5 h were about 3 and 2.5 times as compared with the control values at 1.5 h (Ad: mean +/- s.e. 21.2 +/- 2.8 pg/ml, NA: 55.5 +/- 4.1 pg/ml), respectively. Both 1.0 and 1.5 mg/kg bwt PRZ doses reduced the plasma Ad to below the detection limit (10 pg/ml) and significantly reduced the plasma NA. The 2.5 mg/kg bwt caffeine dose significantly increased plasma Ad and NA during exercise and approximately doubled their maximal values as compared with the saline control (Ad: mean +/- s.e. 12.328 +/- 4.733 ng/ml, NA: 9.997 +/- 4.146 ng/ml). The 1.5 mg/kg bwt PRZ dose decreased the plasma Ad during exercise but the effect was not significant. On the other hand, PRZ significantly increased the plasma NA as compared with the saline control. In conclusion, the present study demonstrates that the plasma catecholamine responses to caffeine and PRZ were modified by exercise. It is probable that the modification may be related to exercise-induced activation of the sympathetico-adrenal axis.
M Kurosawa; S Nagata; F Takeda; K Mima; A Hiraga; M Kai; K Taya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Equine veterinary journal. Supplement     Volume:  -     ISSN:  -     ISO Abbreviation:  Equine Vet J Suppl     Publication Date:  1999 Jul 
Date Detail:
Created Date:  2000-03-02     Completed Date:  2000-03-02     Revised Date:  2013-05-16    
Medline Journal Info:
Nlm Unique ID:  9614088     Medline TA:  Equine Vet J Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  596-600     Citation Subset:  IM    
Laboratory of Racing Chemistry, Tochigi, Japan.
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MeSH Terms
Caffeine / pharmacology*
Central Nervous System Depressants / pharmacology*
Central Nervous System Stimulants / pharmacology*
Doping in Sports*
Epinephrine / blood*
Exercise Test / veterinary
Horses / blood*
Norepinephrine / blood*
Physical Conditioning, Animal*
Promazine / pharmacology*
Reg. No./Substance:
0/Central Nervous System Depressants; 0/Central Nervous System Stimulants; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 58-08-2/Caffeine; 58-40-2/Promazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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