Document Detail

Effects of caffeine on exercise performance of physically fit Thoroughbreds.
MedLine Citation:
PMID:  15900934     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effects of a dose of caffeine (2.5 mg/kg, IV) administered to physically fit Thoroughbreds during incremental exercise testing to fatigue on a treadmill. ANIMALS: 10 conditioned Thoroughbreds. PROCEDURE: Horses were randomly assigned to receive caffeine or a control solution. Each horse received both treatments in a crossover design with a 3-week interval between treatments. Each horse was administered caffeine (2.5 mg/kg) or an equivalent amount of a control solution IV. One hour after injection, each horse performed an incremental exercise test to exhaustion. Hematologic values, heart rate, oxygen consumption, carbon dioxide production, plasma lactate concentration, urine and serum concentrations of caffeine and metabolites, and time until exhaustion were monitored. Statistical analysis was performed by use of a mixed-effects linear model. RESULTS: Significant differences in measured values when horses were treated with caffeine or the control solution were not detected. CONCLUSIONS AND CLINICAL RELEVANCE: A dose of caffeine (2.5 mg/kg, IV) appears to have no effect on any performance variable of physically fit Thoroughbreds during incremental exercise testing to fatigue.
Kathleen A Savage; Patrick T Colahan; Ian R Tebbett; Brett L Rice; Lester L Freshwater; Christie A Jackson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  66     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-05-19     Completed Date:  2005-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  569-73     Citation Subset:  IM    
Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0136, USA.
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MeSH Terms
Caffeine / blood,  pharmacology*,  urine
Carbon Dioxide / metabolism
Central Nervous System Stimulants / blood,  pharmacology*,  urine
Cross-Over Studies
Heart Rate / drug effects,  physiology
Horses / blood,  physiology*,  urine
Lactic Acid / blood
Oxygen Consumption / drug effects,  physiology
Physical Conditioning, Animal / physiology*
Random Allocation
Reg. No./Substance:
0/Central Nervous System Stimulants; 124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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