Document Detail

Effects of caffeic acid phenethyl ester on the histopathological changes in the lungs of cigarette smoke-exposed rabbits.
MedLine Citation:
PMID:  17697039     Owner:  NLM     Status:  MEDLINE    
We aimed at evaluating the effects of caffeic acid phenethyl ester (CAPE) on the histopathological changes in the lungs of rabbits exposed to cigarette smoke exposure. Four groups with six rabbits each were as follows: cigarette smoke group, CAPE group, cigarette smoke + CAPE group and control group. The cigarette smoke group was exposed to cigarette smoke 1 hr daily for 1 month. The CAPE group was administered intraperitoneal CAPE. The CAPE + cigarette smoke group was both exposed to cigarette smoke and was administered intraperitoneal CAPE. The control group was exposed to clean air. After 1 month, the rabbits were killed and the lung tissues were examined histopathologically. Peribronchial and intraparenchymal inflammation, intraparenchymal vascular congestion and thrombosis, intraparenchymal haemorrhage, respiratory epithelial proliferation, number of macrophages in the bronchiolar and alveolar lumen, alveolar destruction, emphysematous changes and bronchoalveolar haemorrhage scores were significantly higher in the cigarette smoke group than in the control group. Administration of CAPE to cigarette smoke-exposed rabbits significantly prevented all these changes. CAPE seems to have significant preventive effects on the severe histopathological changes in the lungs associated with cigarette smoke exposure. However, in some instances, it may not alter the progression to fibrosis.
Murat Sezer; Onder Sahin; Okan Solak; Fatma Fidan; Ziya Kara; Mehmet Unlu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Basic & clinical pharmacology & toxicology     Volume:  101     ISSN:  1742-7835     ISO Abbreviation:  Basic Clin. Pharmacol. Toxicol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2008-01-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101208422     Medline TA:  Basic Clin Pharmacol Toxicol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  187-91     Citation Subset:  IM    
Department of Pulmonary Medicine, Kocatepe University, Afyon, Turkey.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use*
Antioxidants / pharmacology
Caffeic Acids / therapeutic use*
Inflammation / chemically induced,  drug therapy*,  pathology
Lung / drug effects*,  pathology
Phenylethyl Alcohol / analogs & derivatives*,  therapeutic use
Smoke / adverse effects*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antioxidants; 0/Caffeic Acids; 0/Smoke; 104594-70-9/caffeic acid phenethyl ester; 60-12-8/Phenylethyl Alcohol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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