Document Detail

Effects of cadmium ingestion on blood pressure and ventricular mass in rabbits.
MedLine Citation:
PMID:  2977116     Owner:  NLM     Status:  MEDLINE    
Ingestion of cadmium (Cd) acetate in deionized drinking water (1 ppm) in rabbits resulted in the development of hypertension and increased left ventricular mass similar to what was observed in experimental renal hypertension (Grollman technique). Regardless of the approach, mean arterial pressures (MAP) of at least 50 mm Hg greater than those of controls developed over a 34-day period. Increased left ventricular mass relative to body weight was found in both hypertensive groups. However, only an increase in renal mass was observed in unilaterally nephrectomized animals. The increased mass of hearts and kidneys that was detected after an approximately 1-month period attests to the severity of these forms of experimental hypertension. These results demonstrate that the ingestion of drinking water contaminated with Cd can cause hypertension and an increase in left ventricular mass over a short time period in rabbits.
J F Tomera; C Harakal
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Drug-nutrient interactions     Volume:  5     ISSN:  0272-3530     ISO Abbreviation:  Drug Nutr Interact     Publication Date:  1988  
Date Detail:
Created Date:  1989-05-18     Completed Date:  1989-05-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8307198     Medline TA:  Drug Nutr Interact     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  365-72     Citation Subset:  IM    
Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140.
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MeSH Terms
Cadmium / toxicity*
Cardiomegaly / chemically induced*
Disease Models, Animal
Hypertension / chemically induced*
Hypertension, Renal / chemically induced
Kidney / drug effects,  pathology
Grant Support
Reg. No./Substance:

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