| Effects of cadmium ingestion on blood pressure and ventricular mass in rabbits. | |
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MedLine Citation:
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PMID: 2977116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ingestion of cadmium (Cd) acetate in deionized drinking water (1 ppm) in rabbits resulted in the development of hypertension and increased left ventricular mass similar to what was observed in experimental renal hypertension (Grollman technique). Regardless of the approach, mean arterial pressures (MAP) of at least 50 mm Hg greater than those of controls developed over a 34-day period. Increased left ventricular mass relative to body weight was found in both hypertensive groups. However, only an increase in renal mass was observed in unilaterally nephrectomized animals. The increased mass of hearts and kidneys that was detected after an approximately 1-month period attests to the severity of these forms of experimental hypertension. These results demonstrate that the ingestion of drinking water contaminated with Cd can cause hypertension and an increase in left ventricular mass over a short time period in rabbits. |
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Authors:
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J F Tomera; C Harakal |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Drug-nutrient interactions Volume: 5 ISSN: 0272-3530 ISO Abbreviation: Drug Nutr Interact Publication Date: 1988 |
Date Detail:
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Created Date: 1989-05-18 Completed Date: 1989-05-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8307198 Medline TA: Drug Nutr Interact Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 365-72 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cadmium / toxicity* Cardiomegaly / chemically induced* Disease Models, Animal Female Hypertension / chemically induced* Hypertension, Renal / chemically induced Kidney / drug effects, pathology Rabbits |
| Grant Support | |
ID/Acronym/Agency:
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HL 14217/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7440-43-9/Cadmium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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