Document Detail


Effects of cabergoline on reproduction in three families of Australian marsupials.
MedLine Citation:
PMID:  9713388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of the prolactin inhibiting drug, cabergoline, on pregnant and lactating marsupials were investigated in four species from three diverse families: the tammar wallaby, Macropus eugenii, the quokka, Setonix brachyurus, the brushtail possum, Trichosurus vulpecula, and the fat-tailed dunnart, Sminthopsis crassicaudata. In tammar wallabies, 20 micrograms cabergoline kg-1 injected intramuscularly 1 day before expected birth did not alter the timing of parturition but neonates died within a day of birth, suggesting that the onset of lactation was compromised. During early lactation in tammars (56-69 days post partum), an intramuscular injection transiently retarded growth of the young, although they subsequently survived. This treatment induced reactivation of the quiescent corpus luteum and the blastocyst from diapause, so a new birth occurred 26-27 days later, despite the continued sucking of the young in the pouch. Intramuscular injection during late lactation (166-199 days post partum) apparently suppressed milk secretion since pouch young lost up to 20% of their bodyweight or died within 7 days of treatment. Oral administration of cabergoline had no effect on the growth of the young or on the quiescent corpus luteum and diapausing blastocyst. Quokkas showed similar responses to tammars after treatment in late lactation. Possums and dunnarts were less sensitive to injected cabergoline than the two macropodid species, and possums showed no response to oral administration. The lack of response of these marsupial species to oral cabergoline treatment suggests that accidental ingestion of baits, containing 20 micrograms cabergoline kg-1, used to control introduced eutherian pests such as the red fox, Vulpes vulpes, or the feral cat, Felis cattus, should not affect the reproduction of native marsupials.
Authors:
C M Hearn; G Shaw; R V Short; M B Renfree
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of reproduction and fertility     Volume:  113     ISSN:  0022-4251     ISO Abbreviation:  J. Reprod. Fertil.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-09-01     Completed Date:  1998-09-01     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  0376367     Medline TA:  J Reprod Fertil     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  151-7     Citation Subset:  IM    
Affiliation:
Department of Zoology, University of Melbourne, Parkville, Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Animals, Newborn / growth & development
Body Weight / drug effects
Dopamine Agonists / pharmacology*
Ergolines / pharmacology*
Female
Injections, Intramuscular
Lactation / drug effects
Macropodidae
Marsupialia*
Pregnancy
Pregnancy, Animal / drug effects
Prolactin / antagonists & inhibitors*
Reproduction / drug effects*
Chemical
Reg. No./Substance:
0/Dopamine Agonists; 0/Ergolines; 9002-62-4/Prolactin; LL60K9J05T/cabergoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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