Document Detail

Effects of butorphanol, fentanyl and morphine on the intrabiliary pressure of guinea pigs.
MedLine Citation:
PMID:  7361246     Owner:  NLM     Status:  MEDLINE    
Alleged injury to the liver by halogenated hydrocarbon anesthetic agents has led to greater use of balanced anesthesia with analgesics, tranquilizers and nitrous oxide and oxygen. Reports of high intrabiliary pressures and bizarre cholangiograms for patients under such anesthesia led us to investigate the specific effects on intrabiliary pressure of morphine sulfate, fentanyl and butorphanol tartrate, each at two different dosage levels. After control measurements were taken, all of the guinea pigs, an animal with a biliary tract much like that of man, were injected with a different drug, dosage level or with 0.9 per cent saline solution, and changes in intrabiliary pressure were recorded every five minutes. Both high and low dosages of morphine and fentanyl produced marked and statistically significant increases in the intrabiliary pressure. In contrast, equianalgesic dosage of butorphanol produced little or no increase. Since two of these drugs can elevate intrabiliary pressure significantly above pretreatment values, it is recommended that dilations of the biliary tract occurring during operative cholangiograms be interpreted with caution.
F Romo-Salas; J A Aldrete; Y Franatovic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery, gynecology & obstetrics     Volume:  150     ISSN:  0039-6087     ISO Abbreviation:  Surg Gynecol Obstet     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-05-23     Completed Date:  1980-05-23     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101370     Medline TA:  Surg Gynecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  551-4     Citation Subset:  AIM; IM    
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MeSH Terms
Biliary Tract / drug effects*
Butorphanol / pharmacology*
Dose-Response Relationship, Drug
Fentanyl / pharmacology*
Guinea Pigs
Morphinans / pharmacology*
Morphine / pharmacology*
Muscle, Smooth / drug effects
Time Factors
Reg. No./Substance:
0/Morphinans; 42408-82-2/Butorphanol; 437-38-7/Fentanyl; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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