| Effects of butorphanol on feeding and neuropeptide Y in the rat. | |
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MedLine Citation:
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PMID: 21925202 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Butorphanol ([BT] an opioid receptor agonist/antagonist) is different from other opioid agonists in that a single dose of BT can elicit up to 12 g of chow intake in a satiated rat whereas most opioid agonists induce a mild feeding response (2-3 g). Here, we first examined whether the effectiveness of BT to elicit feeding was affected by dose, method of infusion and possible tachyphylaxis following administration. Secondly, we examined whether BT administration influenced hypothalamic NPY gene expression and peptide levels. A single dose administration of BT (4 mg/kg) significantly increased food intake at 2, 3 and 6 h after administration. However following repeated injections of BT at 4 mg/kg, the cumulative long-term intake of BT-treated rats did not differ from that of controls, indicating that the animals compensate for the increased feeding following BT injection by decreased feeding at a later time. An ascending dose schedule of repeated BT injections resulted in additional feeding. NPY gene expression in the ARC was influenced by how much food had been consumed, but not by BT. The amount of food consumed and the level of NPY mRNA were inversely correlated. This is consistent with NPY's role in normal feeding. BT treatment did not affect either NPY or leptin RIA levels. We conclude that the feeding produced by BT is sensitive to dose and dosing paradigm. Further, its mechanism of action does not appear to be mediated by NPY or leptin pathways. |
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Authors:
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A Mitra; C M Kotz; E M Kim; M K Grace; M A Kuskowski; C J Billington; A S Levine |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-09-07 |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 100 ISSN: 1873-5177 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-19 Completed Date: 2012-05-04 Revised Date: 2013-03-05 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: United States |
Other Details:
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Languages: eng Pagination: 575-80 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Inc. |
Affiliation:
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University of Minnesota, Minneapolis, MN, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Opioid
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administration & dosage,
pharmacology* Animals Appetite Stimulants / administration & dosage, pharmacology* Arcuate Nucleus / drug effects*, metabolism Behavior, Animal / drug effects Butorphanol / administration & dosage, pharmacology* Dose-Response Relationship, Drug Energy Intake / drug effects* Food Deprivation Gene Expression Regulation / drug effects Male Narcotic Antagonists / administration & dosage, pharmacology* Nerve Tissue Proteins / genetics, metabolism Neurons / drug effects, metabolism Neuropeptide Y / genetics, metabolism* Organ Specificity RNA, Messenger / metabolism Random Allocation Rats Rats, Sprague-Dawley Tachyphylaxis |
| Grant Support | |
ID/Acronym/Agency:
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DA03999/DA/NIDA NIH HHS; DK42698/DK/NIDDK NIH HHS; R01 DA003999-12A1/DA/NIDA NIH HHS; R01 DK042698-08/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Appetite Stimulants; 0/Narcotic Antagonists; 0/Nerve Tissue Proteins; 0/Neuropeptide Y; 0/RNA, Messenger; 42408-82-2/Butorphanol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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