| Effects of buflomedil on skin blood flow in patients with type 2 diabetes mellitus without overt micro- or macroangiopathy. | |
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MedLine Citation:
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PMID: 21427654 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIM: The aim of this study was to assess the effects of buflomedil on the peripheral microcirculation in patients with type 2 diabetes mellitus (T2DM) without overt micro- or macroangiopathy. METHODS: Twenty-three patients with T2DM were randomly assigned to receive buflomedil 600 mg/day for six months (N.=12) or no medication (N.=11). Skin blood flow in the lower limbs was assessed at baseline and after 3 and 6 months using Laser Doppler. We measured the following laser Doppler parameters: volume, flow and velocity. RESULTS: In patients treated with buflomedil, there was a significant increase in volume (P=0.039) and a trend for an increase in both flow and velocity (P=0.097 for both parameters). In contrast, significant decreases in volume and flow were observed in the control group (P=0.045 and P=0.027, respectively) whereas velocity did not change (P=0.150). CONCLUSION: In conclusion, buflomedil appears to have a beneficial effect on the peripheral microcirculation in patients with T2DM. |
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Authors:
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D Tsantilas; A I Hatzitolios; K Tziomalos; D Karamitsos; D Papadimitriou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International angiology : a journal of the International Union of Angiology Volume: 30 ISSN: 1827-1839 ISO Abbreviation: Int Angiol Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8402693 Medline TA: Int Angiol Country: Italy |
Other Details:
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Languages: eng Pagination: 164-71 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, "Georgios Gennimatas" General Hospital, Thessaloniki, Greece - axatzito@med.auth.gr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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