Document Detail


Effects of buflomedil on early carotid atherosclerosis in Type 2 diabetic patients.
MedLine Citation:
PMID:  11533519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: An increased thickness of the carotid artery wall is thought to be a sign of early atherosclerosis. We have investigated the effect of early treatment with buflomedil on the prevention of the arterial wall thickening. METHODS: Eighty patients with Type 2 diabetes were studied. Oral buflomedil (600 mg once daily) was administered for 12 months in 42 patients randomly selected, while 38 received no treatment. The two groups were matched for age, sex, body mass index (BMI), duration of diabetes and glycaemic control. Arterial wall thickness was measured as the mean of the maximum intima media thickness (IMT) in 8 carotid segments measured by B-mode ultrasound. RESULTS: Blood pressure and lipid levels remained unchanged in the two studied groups while no difference was found in metabolic control between them. The IMT increase over 12 months was 0.04 mm in the buflomedil group whereas in that without buflomedil it was 0.10 mm. CONCLUSIONS: We conclude that buflomedil treatment may be useful in decreasing the progression rate of arterial wall thickness.
Authors:
I N Migdalis; N Varvarigos; J Charalabides; E Leontiades; B Gerolimou; F Mantzara; K Karmaniolas
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  20     ISSN:  0392-9590     ISO Abbreviation:  Int Angiol     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-09-04     Completed Date:  2001-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  126-30     Citation Subset:  IM    
Affiliation:
Department of Diabetes, NIMTS Hospital, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Glucose / drug effects
Blood Pressure / drug effects
Body Mass Index
Carotid Artery Diseases / drug therapy*,  etiology*
Carotid Artery, Common / drug effects,  ultrasonography
Diabetes Mellitus, Type 2 / complications*,  drug therapy*
Female
Follow-Up Studies
Hemoglobin A, Glycosylated / drug effects
Humans
Lipids / blood
Male
Middle Aged
Platelet Aggregation Inhibitors / therapeutic use*
Pyrrolidines / therapeutic use*
Tunica Intima / drug effects,  ultrasonography
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Lipids; 0/Platelet Aggregation Inhibitors; 0/Pyrrolidines; 55837-25-7/buflomedil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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