Document Detail

Effects of bucindolol in heart failure.
MedLine Citation:
PMID:  8096677     Owner:  NLM     Status:  MEDLINE    
Bucindolol hydrochloride is a phenoxypropanolamine with potent nonselective beta antagonist and mild vasodilatory properties. In humans with congestive heart failure, it is extremely well tolerated and produces improvements in left ventricular systolic (ejection fraction, systolic elastance, cardiac index, and stroke work) and diastolic (isovolumic relaxation) performance while reducing pulmonary artery pressures and heart rate. These improvements occur without an increase in myocardial oxygen extraction or oxygen consumption. In addition, functional class improves with this agent although exercise tolerance and maximal oxygen consumption (VO2max) does not change, an effect that is not unexpected with a beta-adrenergic antagonist. Bucindolol produces a decrease in plasma renin activity and plasma norepinephrine, effects that may be beneficial for the long-term treatment of congestive heart failure. However, these effects are most marked in patients with idiopathic dilated cardiomyopathy compared with patients with ischemic heart disease. This agent holds great promise for the treatment of heart failure patients.
E J Eichhorn
Related Documents :
1439197 - Effect of isoproterenol on regional myocardial segment work, o2 consumption, and oxygen...
10841967 - Role of the etiology of cardiomyopathies on exercise capacity and oxygen consumption in...
16344207 - Low cardiac output syndrome: identification and management.
20174637 - Improved energy supply regulation in chronic hypoxic mouse counteracts hypoxia-induced ...
15772177 - Right ventricular infarction complicated by right to left shunting through an atrial se...
24851157 - Emergency neuroendoscopic management of third ventricular neurocysticercosis cyst prese...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  71     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-06     Completed Date:  1993-05-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  65C-70C     Citation Subset:  AIM; IM    
Cardiac Catheterization Laboratory, Dallas Veterans Affairs Hospital, Texas.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Heart Failure / drug therapy*
Hemodynamics / drug effects
Propanolamines / therapeutic use*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Propanolamines; 70369-47-0/bucindolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Therapeutic controversies with use of beta-adrenoceptor blockade in heart failure.
Next Document:  Effect of monoclonal antibody CD4 on glomerulonephritis of ddY mice, a spontaneous animal model of I...