Document Detail


Effects of bucindolol in heart failure.
MedLine Citation:
PMID:  8096677     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bucindolol hydrochloride is a phenoxypropanolamine with potent nonselective beta antagonist and mild vasodilatory properties. In humans with congestive heart failure, it is extremely well tolerated and produces improvements in left ventricular systolic (ejection fraction, systolic elastance, cardiac index, and stroke work) and diastolic (isovolumic relaxation) performance while reducing pulmonary artery pressures and heart rate. These improvements occur without an increase in myocardial oxygen extraction or oxygen consumption. In addition, functional class improves with this agent although exercise tolerance and maximal oxygen consumption (VO2max) does not change, an effect that is not unexpected with a beta-adrenergic antagonist. Bucindolol produces a decrease in plasma renin activity and plasma norepinephrine, effects that may be beneficial for the long-term treatment of congestive heart failure. However, these effects are most marked in patients with idiopathic dilated cardiomyopathy compared with patients with ischemic heart disease. This agent holds great promise for the treatment of heart failure patients.
Authors:
E J Eichhorn
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  71     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-06     Completed Date:  1993-05-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  65C-70C     Citation Subset:  AIM; IM    
Affiliation:
Cardiac Catheterization Laboratory, Dallas Veterans Affairs Hospital, Texas.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use*
Animals
Heart Failure / drug therapy*
Hemodynamics / drug effects
Humans
Propanolamines / therapeutic use*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Propanolamines; 70369-47-0/bucindolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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