| Effects of the bronchoalveolar lavage procedure on lung function in horses with clinical exacerbation of recurrent airway obstruction. | |
| | |
MedLine Citation:
|
PMID: 17078757 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate whether bronchoalveolar lavage (BAL) alters respiratory mechanics of horses with recurrent airway obstruction (ie, heaves) over a 48-hour period. ANIMALS: 6 horses affected with heaves. PROCEDURES: Horses were subjected to a complete BAL procedure, which included sedation with xylazine and butorphanol, intratracheal administration of lidocaine, and instillation and aspiration of two 250-mL boluses of saline (0.9% NaCl) solution through an endoscope (study 1). To evaluate the effects of saline solution, horses were subjected to the same procedure without saline solution instillation and aspiration (study 2). Lastly, the endoscope was similarly introduced into the lower airways, without sedation or saline instillation and aspiration (study 3). Respiratory mechanics were performed at baseline (time 0) and at 3, 6, 12, 24, and 48 hours after each procedure. RESULTS: In study 1, BAL induced a significant decrease in pulmonary resistance lasting up to 6 hours. This may have resulted from clearance of mucus in large airways. We also observed a significant increase in lung elastance and transpulmonary pressure at 12 hours after BAL in all 3 studies, which may be attributed to a circadian effect. CONCLUSIONS AND CLINICAL RELEVANCE: Our results indicate that the temporal effects of BAL procedures on lung mechanics should be taken into account when designing research protocols involving horses with heaves. Future studies should address the immediate effects of BAL on lung function. |
| | |
Authors:
|
Renaud Léguillette; Jean-Pierre Lavoie |
Related Documents
:
|
17124837 - Effects of unilateral laser-assisted ventriculocordectomy in horses with laryngeal hemi... 9031857 - Cardiorespiratory responses to exercise in horses with different grades of idiopathic l... 17543547 - Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan c... 23430667 - Subacute blood pressure response in elderly hypertensive women after a water exercise s... 16083977 - The effect of lead on the metabolic and energetic status of the yabby, cherax destructo... 8000267 - Dobutamine stress echocardiography in clinical practice with a review of the recent lit... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of veterinary research Volume: 67 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 2006 Nov |
Date Detail:
|
Created Date: 2006-11-02 Completed Date: 2007-01-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: United States |
Other Details:
|
Languages: eng Pagination: 1929-33 Citation Subset: IM |
Affiliation:
|
Départment de Sciences Cliniques, Faculté de Médecine Vétérinaire, Université de Montréal, St-Hyacinthe, QC J2S 7C6, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Animals Bronchoalveolar Lavage / methods, veterinary* Horse Diseases / diagnosis*, therapy Horses Lung Diseases, Obstructive / diagnosis, therapy, veterinary* Respiratory Mechanics / physiology* Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Expression of neural markers on bone marrow-derived canine mesenchymal stem cells.
Next Document: Results of vaccination of Asian elephants (Elephas maximus) with monovalent inactivated rabies vacci...