Document Detail


Effects of bronchial vascular engorgement on airway dimensions.
MedLine Citation:
PMID:  8828677     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Airway vascular engorgement has been suggested to cause luminal narrowing and airflow obstruction. To determine the extent to which changes in bronchial vascular volume could influence airway dimensions, we studied the effects of left atrial pressure elevation on airway morphometry in sheep (n = 17). The bronchial branch of the bronchoesophageal artery was cannulated and perfused with autologous blood (0.6 ml.min-1.kg-1). A balloon-tipped catheter was inserted into the left atrial appendage to elevate left atrial pressure by 10 mmHg, and papaverine was infused into the bronchial artery to eliminate airway smooth muscle tone. Morphological measurements were made from rapidly frozen lungs excised in vivo. Left atrial pressure elevation caused a 79% increase in total vascular area (P = 0.0002). Average airway luminal area was significantly decreased from 86 to 71% of the airway maximal area (P < 0.0001). Noteworthy were the prominent bronchial vessels located within mucosal folds. However, when papaverine was infused during left atrial pressure elevation, despite a comparable total vascular area, luminal narrowing did not occur and remained at 87% of the maximal area (P = 0.6267). In conclusion, we found that engorgement of the bronchial vasculature leads to an increase in the vascular area in regions inside and outside the smooth muscle layer. The associated decrease in luminal area only occurs in the presence of airway smooth muscle tone. This suggests a reflex effect on the airway caused by the vascular engorgement. We conclude that vascular engorgement of the airway wall per se has a negligible effect on airway obstruction.
Authors:
E M Wagner; W Mitzner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  81     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-18     Completed Date:  1996-12-18     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  293-301     Citation Subset:  IM    
Affiliation:
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA.
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MeSH Terms
Descriptor/Qualifier:
Airway Resistance / drug effects,  physiology
Anesthesia, General
Animals
Atrial Function
Blood Pressure / drug effects,  physiology
Bronchi / anatomy & histology*,  blood supply*,  drug effects
Functional Residual Capacity
Heart Atria / drug effects
Kinetics
Muscle Tonus / physiology
Muscle, Smooth / anatomy & histology,  physiology
Papaverine / pharmacology
Regional Blood Flow / drug effects,  physiology
Respiratory System / anatomy & histology*,  drug effects
Sheep
Vasodilator Agents / pharmacology
Grant Support
ID/Acronym/Agency:
ES-03819/ES/NIEHS NIH HHS; HL-10342/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 58-74-2/Papaverine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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