| Effects of bromocriptine on pancreatic secretion in the isolated, blood-perfused pancreas of the dog. | |
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MedLine Citation:
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PMID: 6744683 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of bromocriptine on the secretion of pancreatic juice were investigated with dog isolated, blood-perfused pancreas. Bromocriptine (1-10 mg) caused dose-dependent increases in the secretion of pancreatic juice. However, bromocriptine did not affect the perfusion blood flow rate. The secretory response to bromocriptine was inhibited by pretreatment with a dopamine antagonist, sulpiride, but not by phentolamine, propranolol, atropine, metiamide, indomethacin or tetrodotoxin. Bromocriptine caused a dopamine-like secretion of the pancreatic juice containing a high concentration of bicarbonate but had little effect on protein output. These results suggest that bromocriptine increases pancreatic secretion stimulating directly on pancreatic dopamine receptors. |
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Authors:
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K Iwatsuki; F Iijima; S Chiba |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 11 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 1984 May-Jun |
Date Detail:
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Created Date: 1984-09-18 Completed Date: 1984-09-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 231-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Bromocriptine / pharmacology* Dogs Dopamine / pharmacology Dose-Response Relationship, Drug Female Male Pancreas / drug effects*, secretion Pancreatic Juice / secretion Perfusion Receptors, Dopamine / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Dopamine; 25614-03-3/Bromocriptine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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