Document Detail

Effects of bright light and melatonin on sleep propensity, temperature, and cardiac activity at night.
MedLine Citation:
PMID:  11509518     Owner:  NLM     Status:  MEDLINE    
Melatonin increases sleepiness, decreases core temperature, and increases peripheral temperature in humans. Melatonin may produce these effects by activating peripheral receptors or altering autonomic activity. The latter hypothesis was investigated in 16 supine subjects. Three conditions were created by using bright light and exogenous melatonin: normal endogenous, suppressed, and pharmacological melatonin levels. Data during wakefulness from 1.5 h before to 2.5 h after each subject's estimated melatonin onset (wake time + 14 h) were analyzed. Respiratory sinus arrhythmia (cardiac parasympathetic activity) and preejection period (cardiac sympathetic activity) did not vary among conditions. Pharmacological melatonin levels significantly decreased systolic blood pressure [5.75 +/- 1.65 (SE) mmHg] but did not significantly change heart rate. Suppressed melatonin significantly increased rectal temperature (0.27 +/- 0.06 degrees C), decreased foot temperature (1.98 +/- 0.70 degrees C), and increased sleep onset latency (5.53 +/- 1.87 min). Thus melatonin does not significantly alter cardiac autonomic activity and instead may bind to peripheral receptors in the vasculature and heart. Furthermore, increases in cardiac parasympathetic activity before normal nighttime sleep cannot be attributed to the concomitant increase in endogenous melatonin.
H J Burgess; T Sletten; N Savic; S S Gilbert; D Dawson
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  91     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-08-17     Completed Date:  2001-12-18     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1214-22     Citation Subset:  IM; S    
Centre for Sleep Research, University of South Australia, Woodville, South Australia 5011, Australia.
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MeSH Terms
Anticonvulsants / administration & dosage*,  analysis
Arrhythmia, Sinus / physiopathology
Blood Pressure / drug effects,  physiology
Body Temperature / drug effects,  physiology
Circadian Rhythm / drug effects,  physiology*
Heart Rate / drug effects,  physiology*
Melatonin / administration & dosage*,  analysis
Saliva / chemistry
Sleep / drug effects,  physiology*
Sympathetic Nervous System / physiology
Reg. No./Substance:
0/Anticonvulsants; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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