Document Detail

Effects of brief, clustered versus dispersed hypoxic episodes on systemic and ocular growth factors in a rat model of oxygen-induced retinopathy.
MedLine Citation:
PMID:  18344903     Owner:  NLM     Status:  MEDLINE    
Oxygen fluctuation patterns in preterm infants who develop retinopathy of prematurity (ROP) are varied and poorly represented in animal models. We examined the hypothesis that clustered (CL) episodes of hypoxia during hyperoxia results in a more severe form of oxygen-induced retinopathy (OIR) than dispersed episodes. Rat pups were exposed to alternating cycles of 1) 50% O2 with three CL episodes of 12% O2 every 6 h; or 2) 50% O2 with one episode of 12% O2 every 2 h, for 7 (P7) or 14 (P14) days postnatal age. Pups were killed after hyperoxia, or placed in room air (RA) until P21. RA littermates were killed at P7, P14, and P21. Systemic and ocular vascular endothelial growth factor (VEGF), soluble VEGFR-1 (sVEGFR-1), insulin-like growth factor I (IGF-I), and growth hormone were examined. All hyperoxia-exposed retinas had evidence of neovascularization. Animals in the CL group had a more severe form of OIR at P21 evidenced by vascular tufts, leaky vessels, retinal hemorrhage, and vascular overgrowth. These characteristics were associated with low body weight; high systemic and ocular VEGF; and low systemic and high ocular sVEGFR-1 and IGF-I. These data suggest that preterm infants who experience CL fluctuations in Pao2 during supplemental O2 therapy are at a higher risk for severe ROP.
Rebecca J Coleman; Kay D A Beharry; Romy S Brock; Patricia Abad-Santos; Matthew Abad-Santos; Houchang D Modanlou
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  64     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-26     Completed Date:  2008-08-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  50-5     Citation Subset:  IM    
Department of Pediatrics, University of California Irvine, Irvine, California 92868, USA.
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MeSH Terms
Anoxia / complications*,  metabolism,  pathology
Body Weight
Disease Models, Animal
Gestational Age
Growth Hormone / metabolism
Hyperoxia / complications*,  metabolism,  pathology
Infant, Newborn
Insulin-Like Growth Factor I / metabolism*
Rats, Sprague-Dawley
Retina / metabolism*,  pathology
Retinal Neovascularization / etiology,  metabolism
Retinopathy of Prematurity / etiology,  metabolism*,  pathology
Severity of Illness Index
Vascular Endothelial Growth Factor A / blood,  metabolism*
Vascular Endothelial Growth Factor Receptor-1 / metabolism
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A; 0/vascular endothelial growth factor A, rat; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone; EC Endothelial Growth Factor Receptor-1

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