| Effects of branched-chain amino acid-enriched nutrient for patients with hepatocellular carcinoma following radiofrequency ablation: a one-year prospective trial. | |
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MedLine Citation:
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PMID: 20796154 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIM: This prospective control study examined whether supplementation with branched-chain amino acid (BCAA)-enriched nutrients can help maintain and improve residual liver function and nutritional status in cirrhotic patients with hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). METHODS: Subjects were 49 patients with hepatitis C-related HCC who underwent RFA. Two groups were formed: BCAA group (BCAA-enriched nutrient, aminoleban EN) and controls (standard diet only). Event-free survival rate, liver function tests, and Short Form (SF)-8 scores were evaluated in both groups before and one year after RFA. Energy metabolism using indirect calorimetry was measured before and after 3 months. RESULTS: Complete data were obtained from 35 patients (BCAA group, n = 20; controls, n = 15). Six events (death, recurrence of HCC, rupture of esophageal varices and liver failure) occurred during the observation period, but frequencies of these events did not differ between groups. Event-free survival rate tended to be higher in the BCA group than in controls. Among the parameters of liver function, serum albumin level was only significantly increased over 6 months, and remained at similar values for one year (P < 0.05). SF-8 scores for general health, physical functioning, and social functioning were significantly elevated in the BCAA group (P < 0.05). Non-protein respiratory quotient was significantly improved in the BCAA group (P < 0.01). CONCLUSION: Supplementation with BCAA-enriched nutrients for one year in cirrhotic patients with HCC after RFA therapy can perform safety and improve both nutritional state and quality of life. |
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Authors:
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Hidekatsu Kuroda; Akira Ushio; Yasuhiro Miyamoto; Kei Sawara; Kanta Oikawa; Kazuhiro Kasai; Ryujin Endo; Yasuhiro Takikawa; Akinobu Kato; Kazuyuki Suzuki |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: 25 ISSN: 1440-1746 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-27 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: Australia |
Other Details:
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Languages: eng Pagination: 1550-5 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical University, Morioka, Iwate, Japan. hikuro@iwate-med.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amino Acids, Branched-Chain / administration & dosage* Carcinoma, Hepatocellular / complications, mortality, physiopathology, surgery, therapy* Catheter Ablation* / adverse effects Dietary Supplements* Disease Progression Disease-Free Survival Energy Intake Female Humans Kaplan-Meier Estimate Liver / physiopathology, surgery* Liver Function Tests Liver Neoplasms / complications, mortality, physiopathology, surgery, therapy* Male Middle Aged Nutritional Status Nutritional Support* Prospective Studies Protein-Energy Malnutrition / etiology, physiopathology, therapy* Quality of Life Questionnaires Survival Rate Time Factors Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Branched-Chain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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