Document Detail

Effects of branched-chain amino acid-enriched nutrient for patients with hepatocellular carcinoma following radiofrequency ablation: a one-year prospective trial.
MedLine Citation:
PMID:  20796154     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM: This prospective control study examined whether supplementation with branched-chain amino acid (BCAA)-enriched nutrients can help maintain and improve residual liver function and nutritional status in cirrhotic patients with hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA).
METHODS: Subjects were 49 patients with hepatitis C-related HCC who underwent RFA. Two groups were formed: BCAA group (BCAA-enriched nutrient, aminoleban EN) and controls (standard diet only). Event-free survival rate, liver function tests, and Short Form (SF)-8 scores were evaluated in both groups before and one year after RFA. Energy metabolism using indirect calorimetry was measured before and after 3 months.
RESULTS: Complete data were obtained from 35 patients (BCAA group, n = 20; controls, n = 15). Six events (death, recurrence of HCC, rupture of esophageal varices and liver failure) occurred during the observation period, but frequencies of these events did not differ between groups. Event-free survival rate tended to be higher in the BCA group than in controls. Among the parameters of liver function, serum albumin level was only significantly increased over 6 months, and remained at similar values for one year (P < 0.05). SF-8 scores for general health, physical functioning, and social functioning were significantly elevated in the BCAA group (P < 0.05). Non-protein respiratory quotient was significantly improved in the BCAA group (P < 0.01).
CONCLUSION: Supplementation with BCAA-enriched nutrients for one year in cirrhotic patients with HCC after RFA therapy can perform safety and improve both nutritional state and quality of life.
Hidekatsu Kuroda; Akira Ushio; Yasuhiro Miyamoto; Kei Sawara; Kanta Oikawa; Kazuhiro Kasai; Ryujin Endo; Yasuhiro Takikawa; Akinobu Kato; Kazuyuki Suzuki
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  25     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-27     Completed Date:  2010-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1550-5     Citation Subset:  IM    
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical University, Morioka, Iwate, Japan.
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MeSH Terms
Amino Acids, Branched-Chain / administration & dosage*
Carcinoma, Hepatocellular / complications,  mortality,  physiopathology,  surgery,  therapy*
Catheter Ablation* / adverse effects
Dietary Supplements*
Disease Progression
Disease-Free Survival
Energy Intake
Kaplan-Meier Estimate
Liver / physiopathology,  surgery*
Liver Function Tests
Liver Neoplasms / complications,  mortality,  physiopathology,  surgery,  therapy*
Middle Aged
Nutritional Status
Nutritional Support*
Prospective Studies
Protein-Energy Malnutrition / etiology,  physiopathology,  therapy*
Quality of Life
Survival Rate
Time Factors
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Amino Acids, Branched-Chain

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