Document Detail

Effects of brain natriuretic peptide-32 on the extinction of active avoidance behavior in rats. Transmitter-mediated action.
MedLine Citation:
PMID:  1355918     Owner:  NLM     Status:  MEDLINE    
Three doses of porcine brain natriuretic peptide (pBNP-32) were tested in regards to the extinction of active avoidance behavior following injection into the lateral brain ventricle in rats. This peptide delayed the extinction of the active avoidance reflex in a dose-dependent manner. To clarify the involvement of transmitters in the action of the peptide, the animals were pretreated with different receptor blockers in doses that did not affect the behavior of the animals in this learning paradigm. Dopaminergic, cholinergic, and alpha- and beta-adrenergic blockers effectively blocked the delaying action of pBNP-32, whereas GABAergic, serotoninergic, and opiateergic blockers were ineffective. The data suggest that the delaying action of pBNP-32 on the extinction of active avoidance behavior is mediated via dopaminergic and alpha- and beta-adrenergic neuromediations.
A Bidzseranova; J Gueron; J Varga; G Telegdy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  52     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-10-15     Completed Date:  1992-10-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  227-9     Citation Subset:  IM    
Institute of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
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MeSH Terms
Atropine / pharmacology
Avoidance Learning / drug effects*
Extinction, Psychological / drug effects*
Haloperidol / pharmacology
Natriuretic Peptide, Brain
Nerve Tissue Proteins / pharmacology*
Neurotransmitter Agents / physiology*
Phenoxybenzamine / pharmacology
Propranolol / pharmacology
Rats, Inbred Strains
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/Neurotransmitter Agents; 114471-18-0/Natriuretic Peptide, Brain; 51-55-8/Atropine; 52-86-8/Haloperidol; 525-66-6/Propranolol; 59-96-1/Phenoxybenzamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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