Document Detail


Effects of botulinum toxin A on fracture healing in rats: an experimental study.
MedLine Citation:
PMID:  22825767     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Fracture healing is a complex process influenced by intrinsic and extrinsic factors. The aim of the present study was to evaluate the effects of botulinum toxin (BTX) A on fracture healing. MATERIALS AND METHODS: Following the induction of bilateral standard closed femoral fractures and relative fixation in 18 Wistar albino rats, 8 IU of BTX A were injected into the right femoral region. After 28 days, all of the rats were sacrificed, the diameter of the callus was measured, and fracture healing was assessed by biomechanical and histopathologic evaluation. RESULTS: While an increase in biomechanical and histopathologic healing was noted on the side injected with BTX A, a decrease in callus diameter was observed. CONCLUSION: Botulinum toxin A administration increases the healing power in a relatively fixated fracture and decreases the callus diameter, just as if rigid fixation had been performed. The beneficial effect of BTX A on fracture healing might be associated with increased fixation rigidity.
Authors:
Adem Aydin; Kaya Memisoglu; Abdulkadir Cengiz; Halil Atmaca; Bahar Muezzinoglu; Umit Sefa Muezzinoglu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-24
Journal Detail:
Title:  Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association     Volume:  -     ISSN:  1436-2023     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9604934     Medline TA:  J Orthop Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Orthopaedics and Traumatology, Izmit Seka State Hospital, Kocaeli, Turkey.
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