| Effects of bosentan on the skin lesions: an observational study from a single center in Japan. | |
| | |
MedLine Citation:
|
PMID: 19037604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Effects of a dual endothelin receptor antagonist, bosentan on peripheral circulatioin and skin lesions as well as pulmonary arterial hypertension (PAH) were investigated in Japanese patients with connective tissue diseases (CTD). Fifteen patients with PAH associated with CTD [systemic sclerosis (SSc) 13, mixed connective tissue disease (MCTD) 2] were treated with bosentan for 40-96 weeks, and changes of exercise capacity (6-min walk distance and Borg's dyspnea scale), cardio-pulmonary hemodynamics (right ventricular pressure, specific activity scale and cardiac index), Raynaud's phenomenon, digital ulcers and dermal sclerosis were observed. Bosentan improved exercise capacity, had a positive effect on hemodynamic parameters, and was well tolerated as previously reported. After a median 8 weeks of treatment, 13 out of 15 patients had improved Raynaud's phenomenon. Digital ulcers also improved after a median 12 weeks' treatment in all of 8 patients. Modified Rodnan total skin score decreased from 21.0 +/- 5.9 to 11.5 +/- 3.9 in diffuse cutaneous SSc and from 17.0 +/- 6.5 to 9.5 +/- 4.5 in limited cutaneous SSc after 24 months' treatment, reaching significance after 6 months in both groups. These data suggest that bosentan is effective for both PAH and peripheral vascular diseases in Japanese patients with CTD. The pathological background to the improvement in dermal sclerosis observed in this study should be further investigated. |
| | |
Authors:
|
Masanori Funauchi; K Kishimoto; H Shimazu; Y Nagare; S Hino; T Yano; K Kinoshita |
Related Documents
:
|
12140474 - Treatment of pseudofolliculitis barbae in skin types iv, v, and vi with a long-pulsed n... 16442044 - Photo-epilation results of axillary hair in dark-skinned patients by intense pulsed lig... 8981334 - Comparison of two estradiol transdermal systems (oesclim 50 and estraderm tts 50). ii. ... 16537214 - Evaluation of a combined laser-radio frequency device (polaris wr) for the nonablative ... 9632874 - A randomized, controlled, clinical study of laparoscopic vs open tension-free inguinal ... 8210234 - Treatment of guillain-barré syndrome with high-dose immune globulins combined with met... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-27 |
Journal Detail:
|
Title: Rheumatology international Volume: 29 ISSN: 1437-160X ISO Abbreviation: Rheumatol. Int. Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-05-01 Completed Date: 2009-09-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
|
Languages: eng Pagination: 769-75 Citation Subset: IM |
Affiliation:
|
Department of Nephrology and Rheumatology, Kinki University School of Medicine, 377-2 Ohnohigashi, Osaka-Sayama, Osaka, 589-8511, Japan. mn-funa@med.kindai.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Antihypertensive Agents / administration & dosage*, adverse effects Arteries / drug effects, immunology, physiopathology Connective Tissue Diseases / complications, drug therapy*, physiopathology Exercise Tolerance / drug effects, physiology Female Humans Hypertension, Pulmonary / drug therapy*, immunology, physiopathology Japan Male Middle Aged Mixed Connective Tissue Disease / complications, drug therapy, physiopathology Prospective Studies Pulmonary Artery / drug effects, immunology, physiopathology Raynaud Disease / drug therapy, immunology, physiopathology Scleroderma, Systemic / complications, drug therapy, physiopathology Skin Diseases / drug therapy*, immunology, physiopathology Sulfonamides / administration & dosage*, adverse effects Ulcer / drug therapy, immunology, physiopathology Vasculitis / drug therapy*, immunology, physiopathology |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 0/Sulfonamides; 147536-97-8/bosentan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prophylactic use of lamivudine with chronic immunosuppressive therapy for rheumatologic disorders.
Next Document: Prevalence of Behcet's syndrome in patients with recurrent aphthous ulcerations in Brazil.