| Effects of bosentan on neointimal response following coronary angioplasty. | |
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MedLine Citation:
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PMID: 12925035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Endothelins are important vasoconstrictors and cellular-growth promoters. ETA-specific antagonists have been shown to reduce neointimal response to injury in some experimental angioplasty models. However, there is little information on the effects of dual ETA/ETB receptor blockers, such as bosentan, on neointimal proliferation following experimental coronary angioplasty. MATERIALS AND METHODS: Coronary injury was achieved by directional atherectomy in the left anterior descending artery of 20 pigs. Animals were randomly assigned to receive a daily dose of oral bosentan (30 mg kg-1) (group I, n = 10) or no treatment (group II, n = 10). At 4 weeks, arteries were processed for histomorphometry and endothelin characterization. RESULTS: Vessel injury score was similar among the two groups. Overall, a linear correlation was found between injury and neointimal development (r = 0.57, P = 0.01). This correlation had a lower slope in group I compared with group II (P < 0.001), indicating a smaller amount of neointimal development for a similar degree of injury in bosentan-treated animals. Multivariate regression showed that neointimal response was reduced by oral treatment with bosentan (beta: -0.59 mm2, 95% CI: -1.11/-0.06 mm2). In addition, immunostaining revealed fewer positive endothelin areas in group I arteries. CONCLUSIONS: Oral treatment with bosentan reduces neointimal development following coronary angioplasty in this experimental model. |
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Authors:
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M Sanmartín; A Fernández-Ortiz; P Fantidis; P Aragoncillo; R Fernández-Durango; R Rollín; F Alfonso; R Hernández; J Escaned; C Macaya |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of clinical investigation Volume: 33 ISSN: 0014-2972 ISO Abbreviation: Eur. J. Clin. Invest. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-08-19 Completed Date: 2003-11-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0245331 Medline TA: Eur J Clin Invest Country: England |
Other Details:
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Languages: eng Pagination: 762-8 Citation Subset: IM |
Affiliation:
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Cardiovascular Institute, San Carlos University Hospital, Madrid, Spain. marcelo.sanmartin.fernandez@sergas.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Angioplasty / methods* Animals Antihypertensive Agents / administration & dosage, pharmacology* Coronary Restenosis / etiology, physiopathology Coronary Vessels / drug effects* Disease Models, Animal Endothelin-1 / analysis Hemodynamics / drug effects Immunohistochemistry / methods Receptors, Endothelin / antagonists & inhibitors Sulfonamides / administration & dosage, pharmacology* Swine Tunica Intima / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Endothelin-1; 0/Receptors, Endothelin; 0/Sulfonamides; 147536-97-8/bosentan |
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