Document Detail

Effects of boric acid supplementation on bone histomorphometry, metabolism, and biomechanical properties in aged female F-344 rats.
MedLine Citation:
PMID:  12835499     Owner:  NLM     Status:  MEDLINE    
Postmenopausal women may benefit from dietary interventions in order to increase bone strength and prevent fractures. Dietary boron (B) may be beneficial for optimal calcium metabolism and, as a consequence, optimal bone metabolism. The present study evaluated the effects of boron, in the form of boric acid, with or without 17beta-estradiol (E2) supplementation (via subcutaneous implant), in ovariectomized (OVX) aged 13- mo-old F-344 rats. Boric acid was administered by gavage at a subtoxic dose (8.7 mg B/kg/d) for 40 d. Results indicate that serum level of minerals as well as osteocalcin (a marker of bone resorption) are dependent to a greater extent on the hormonal status of the animals than on boron supplementation. Boron treatment increased the E2-induced elevation of urinary calcium and magnesium. Bone mineral density (BMD) of the L5 vertebra and proximal femur was highest in the E2-treated groups; no increase in BMD was conferred by boron treatment. By histomorphometry of the proximal tibial metaphysis, osteoblastic, osteoid, and eroded surfaces were significantly suppressed by E2 treatment, but not by boron treatment. In biomechanical testing of femur and vertebra, neither E2 nor boron treatment significantly increased bone strength. At the levels given, boron alone provided no protection against OVX-induced osteopenia. In addition, combination therapy (B + E2) provided no additional benefits over those of 17beta-estradiol treatment alone in this aged rat model.
Maria T Gallardo-Williams; Robert R Maronpot; Charles H Turner; Christopher S Johnson; Martha W Harris; Manuel J Jayo; Robert E Chapin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological trace element research     Volume:  93     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2003  
Date Detail:
Created Date:  2003-07-01     Completed Date:  2004-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  155-70     Citation Subset:  IM    
Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
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MeSH Terms
Aging / physiology*
Bone Density / drug effects*
Bone and Bones / drug effects*,  metabolism*,  physiology
Boric Acids / administration & dosage,  pharmacology*
Dietary Supplements*
Estradiol / pharmacology
Femur / drug effects,  metabolism,  physiology
Rats, Inbred F344
Tibia / drug effects,  metabolism,  physiology
Time Factors
Reg. No./Substance:
0/Boric Acids; 11113-50-1/boric acid; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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