| Effects of bone morphogenetic protein-7 (BMP-7) on primordial follicular growth in the mouse ovary. | |
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MedLine Citation:
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PMID: 15293217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previously, bone morphogenetic protein-7 (BMP-7) was suggested as a factor that may act to facilitate the transition of follicles from primordial stage to the pool of developed primary, preantral, and antral follicles (Lee et al. 2001: Biol Reprod 65:994-999.). Thus, aim of the present study was to evaluate effect(s) of BMP-7 on the primordial-primary follicle transition. Neonatal mouse ovaries were cultured in the presence or absence of 100 mIU/ml FSH with various doses of BMP-7 (0, 10, and 100 ng/ml). After 4-day culture period, number of follicles was counted and the expression of transcripts for FSH receptor (FSHR), kit ligand (KL), and c-kit was measured by RT-PCR. BMP-7 alone at 100 ng/ml concentration stimulated follicle development with concurrent increase of mRNA for FSHR. BMP-7 alone down-regulated KL expression however, the ratio between KL1 and KL2 was increased. There was no change in the c-kit mRNA expression. Results of the present study suggest that the BMP-7 is one of the factors involved in primordial-primary follicle transition in the mouse ovary and it may play a role in expression of FSHR for further follicular development. |
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Authors:
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Woo-Sik Lee; Se-Jin Yoon; Tae-Ki Yoon; Kwang-Yul Cha; Sook-Hwan Lee; Shunichi Shimasaki; Sangho Lee; Kyung-Ah Lee |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular reproduction and development Volume: 69 ISSN: 1040-452X ISO Abbreviation: Mol. Reprod. Dev. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-08-04 Completed Date: 2005-11-15 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8903333 Medline TA: Mol Reprod Dev Country: United States |
Other Details:
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Languages: eng Pagination: 159-63 Citation Subset: IM |
Affiliation:
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Infertility Medical Center, CHA General Hospital, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins / physiology* Female Follicle Stimulating Hormone / biosynthesis Mice Mice, Inbred ICR Organ Culture Techniques Ovarian Follicle / metabolism, physiology* Proto-Oncogene Proteins c-kit / biosynthesis Receptors, FSH / biosynthesis Stem Cell Factor / biosynthesis Transforming Growth Factor beta / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Bone Morphogenetic Protein 7; 0/Bone Morphogenetic Proteins; 0/Receptors, FSH; 0/Stem Cell Factor; 0/Transforming Growth Factor beta; 9002-68-0/Follicle Stimulating Hormone; EC 2.7.10.1/Proto-Oncogene Proteins c-kit |
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