Document Detail

Effects of body temperature on ventilator-induced lung injury.
MedLine Citation:
PMID:  16015518     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the effects of body temperature on ventilator-induced lung injury. MATERIAL AND METHODS: Thirty-four male Sprague-Dawley rats were randomized into 6 groups based on their body temperature (normothermia, 37 +/- 1 degrees C; hypothermia, 31 +/- 1 degrees C; hyperthermia, 41 +/- 1 degrees C). Ventilator-induced lung injury was achieved by ventilating for 1 hour with pressure-controlled ventilation mode set at peak inspiratory pressure (PIP) of 30 cmH2O (high pressure, or HP) and positive end-expiratory pressure (PEEP) of 0 cmH2O. In control subjects, PIP was set at 14 cmH2O (low pressure, or LP) and PEEP set at 0 cmH2O. Systemic chemokine and cytokine (tumor necrosis factor alpha , interleukin 1 beta , interleukin 6, and monocyte chemoattractant protein 1) levels were measured. The lungs were assessed for histological changes. RESULTS: Serum chemokines and cytokines were significantly elevated in the hyperthermia HP group compared with all 3 groups, LP (control), normothermia HP, and hypothermia HP. Oxygenation was better but not statistically significant in hypothermia HP compared with other HP groups. Cumulative mean histology scores were higher in hyperthermia HP and normothermia HP groups compared with control and normothermia HP groups. CONCLUSIONS: Concomitant hyperthermia increased systemic inflammatory response during HP ventilation. Although hypothermia decreased local inflammation in the lung, it did not completely attenuate systemic inflammatory response associated with HP ventilation.
Ozkan I Akinci; Mehmet Celik; Gökhan M Mutlu; Janice M Martino; Simru Tugrul; Perihan E Ozcan; Dilek Yilmazbayhan; Anjana V Yeldandi; Kemal H Turkoz; Bayram Kiran; Lütfi Telci; Nahit Cakar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of critical care     Volume:  20     ISSN:  0883-9441     ISO Abbreviation:  J Crit Care     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-07-14     Completed Date:  2005-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610642     Medline TA:  J Crit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  66-73     Citation Subset:  IM    
Department of Anesthesiology and Intensive Care, Istanbul Medical Faculty, Capa, Turkey.
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MeSH Terms
Cytokines / blood
Disease Models, Animal
Hyperthermia, Induced
Hypothermia, Induced
Inflammation / etiology,  therapy
Random Allocation
Rats, Sprague-Dawley
Respiratory Distress Syndrome, Adult / etiology*,  pathology,  therapy*
Ventilators, Mechanical / adverse effects*
Reg. No./Substance:

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