Document Detail

Effects of blood medium supplements on activities of newer cephalosporins tested against enterococci.
MedLine Citation:
PMID:  8150978     Owner:  NLM     Status:  MEDLINE    
This comparative study determined the effect of blood on the antienterococcal activities of the newer cephalosporins. Standardized disk diffusion susceptibility tests were performed with 57 strains of enterococci (30 Enterococcus faecalis strains) on Mueller-Hinton agar with and without 5% sheep blood supplementation. Twelve cephalosporins representing five different structural groups (based on the 7-alpha position substitution) were tested. The greatest frequency of activity enhancement by blood was observed with cefdaloxime and cefdinir (7-alpha hydroxyimino group) against E. faecalis. Cephalosporins with a 7-alpha methoxyimino group (cefpodoxime, cefepime, and cefpirome) had marked increases in zone diameters (3 to > 9 mm) when tested with the blood supplement. Cephems with 7-alpha amino or carboxy substitutions did not demonstrate any enhanced activity. Awareness of this phenomenon is important for the interpretation and accuracy of cephalosporin susceptibility testing.
B J Buschelman; R N Jones; M J Bale
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  32     ISSN:  0095-1137     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-05-06     Completed Date:  1994-05-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  565-7     Citation Subset:  IM    
Medical Microbiology Division, University of Iowa College of Medicine, Iowa City 52242.
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MeSH Terms
Cephalosporins / pharmacology*
Culture Media
Drug Resistance, Microbial
Enterococcus / drug effects*,  isolation & purification
Enterococcus faecalis / drug effects,  isolation & purification
Evaluation Studies as Topic
Microbial Sensitivity Tests / methods*
Reg. No./Substance:
0/Cephalosporins; 0/Culture Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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