Document Detail

Effects of blockers of carbohydrate and lipid metabolism on expression of mRNA of some hypothalamic neuropeptides.
MedLine Citation:
PMID:  11177238     Owner:  NLM     Status:  MEDLINE    
The effects of single injections of 2-deoxyglucose or 2-mercaptoacetate on the expression of mRNA of neuropeptide Y, pro-opiomelanocortin, and melanin-concentrating hormone in rat hypothalamus were studied by in situ hybridization in order to elucidate the role of these neuropeptides in the mechanisms of alimentary behavior caused by decreased levels of available fatty acids and glucose. The levels of neuropeptide Y mRNA in arcuate nuclei neurons are significantly increased under conditions of glucose deficiency, while the synthesis of melanin-concentrating hormone in the lateral hypothalamic neurons is increased in fatty acid deficiency. These data indicate that glyco- and lipodeprivation are different metabolic signals activating various neuropeptide systems responsible for alimentary behavior.
V G Sergeev; I G Akmaev
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  130     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-04-26     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  766-8     Citation Subset:  IM    
Institute of Experimental Endocrinology, Endocrinology Research Center, Russian Academy of Medical Sciences.
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MeSH Terms
Carbohydrate Metabolism*
Deoxyglucose / pharmacology
Fatty Acids / metabolism
Gene Expression / drug effects
Glucose / deficiency
Hypothalamic Hormones / genetics
Hypothalamus / drug effects*,  metabolism*
Lipid Metabolism*
Melanins / genetics
Neuropeptide Y / genetics
Neuropeptides / genetics*
Pituitary Hormones / genetics
Pro-Opiomelanocortin / genetics
RNA, Messenger / genetics*,  metabolism*
Rats, Sprague-Dawley
Thioglycolates / pharmacology
Reg. No./Substance:
0/Fatty Acids; 0/Hypothalamic Hormones; 0/Melanins; 0/Neuropeptide Y; 0/Neuropeptides; 0/Pituitary Hormones; 0/RNA, Messenger; 0/Thioglycolates; 154-17-6/Deoxyglucose; 50-99-7/Glucose; 66796-54-1/Pro-Opiomelanocortin; 67382-96-1/melanin-concentrating hormone; 68-11-1/2-mercaptoacetate

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