Document Detail


Effects of black grape extract on activities of DNA turn-over enzymes in cancerous and non cancerous human colon tissues.
MedLine Citation:
PMID:  15820509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effects of extract of dried whole black grape including seed on adenosine deaminase (ADA), 5' nucleotidase (5'NT) and xanthine oxidase (XO) enzymes were investigated in cancerous and non-cancerous human colon tissues. Enzyme activities were measured in 20 colon tissues, 10 from cancerous region and 10 from non cancerous region with and without pre incubation with black grape extract. ADA and 5'NT activities were found increased and that of the XO decreased in the cancerous tissues relative to non cancerous ones. After incubation period with black grape extract for 12 h, ADA and 5'NT activities were found to be significantly lowered but that of XO unchanged in both cancerous and non cancerous tissues. Results suggest that ADA and 5'NT activities increase but XO activity decreases in cancerous human colon tissues, which may provide advantage to the cancerous tissues in obtaining new nucleotides for rapid DNA synthesis through accelerated salvage pathway activity. Black grape extract makes significant inhibition on the ADA and 5'NT activities of cancerous and non cancerous colon tissues, thereby eliminating this advantage of cancer cells, which might be the basis for the beneficial effect of black grape in some kinds of human cancers.
Authors:
Ilker Durak; Recep Cetin; Erdinç Devrim; Imge B Ergüder
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-01-28
Journal Detail:
Title:  Life sciences     Volume:  76     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-11     Completed Date:  2005-06-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2995-3000     Citation Subset:  IM    
Affiliation:
Ankara University School of Medicine, Department of Biochemistry, 06100 Sihhiye, Ankara, Turkey. ilker_durak@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
5'-Nucleotidase / antagonists & inhibitors
Adenocarcinoma / enzymology*
Adenosine Deaminase / antagonists & inhibitors
Colon / cytology,  drug effects*
Colonic Neoplasms / enzymology*
Fruit / chemistry*
Humans
Plant Extracts / pharmacology
Turkey
Vitis / chemistry*
Xanthine Oxidase / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Plant Extracts; EC 1.17.3.2/Xanthine Oxidase; EC 3.1.3.5/5'-Nucleotidase; EC 3.5.4.4/Adenosine Deaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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