Document Detail

Effects of bisphosphonates on sutural bone formation and relapse: A histologic and immunohistochemical study.
MedLine Citation:
PMID:  21724069     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: The aim of this experimental study was to evaluate the effects of systemically applied zoledronic acid on bone regeneration in response to expansion of the sagittal suture and relapse in rats.
METHODS: Thirty-six male Wistar rats were divided into 3 groups. In the first and second groups, saline solution was given subcutaneously after expansion, and the retention periods lasted 14 and 7 days, respectively. In the third group, 0.1 mg of zoledronic acid was diluted with saline solution and given subcutaneously after expansion; the retention period lasted for 7 days. Expansion and relapse amounts were measured by using computed tomography. After the retention period, 6 rats from each group were killed for histologic and immunohistochemical assessments. The other 6 rats from each group were used for observation of the relapse.
RESULTS: The histologic evaluation showed that, in groups 1 and 2, the numbers of osteoblasts were less than observed in group 3. When scores of staining intensity were compared, immunoreactivities were statistically significantly increased in group 3 compared with groups 2 and 1. Statistically significant differences were found when the relapse percentages were compared between the groups (P <0.05). The smallest relapse occurred in group 3.
CONCLUSIONS: Zoledronic acid has positive effects on bone formation in the sagittal suture in response to expansion and decreases the relapse ratio after expansion in rats.
Fırat Oztürk; Hasan Babacan; Sevinç Inan; Cesur Gümüş
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics     Volume:  140     ISSN:  1097-6752     ISO Abbreviation:  Am J Orthod Dentofacial Orthop     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610224     Medline TA:  Am J Orthod Dentofacial Orthop     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e31-41     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2011 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.
Assistant professor, Department of Orthodontics, Faculty of Dentistry, İnönü University, Malatya, Turkey.
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