Document Detail


Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndrome.
MedLine Citation:
PMID:  19433247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bisphenol A (BPA) is one of the most prevalent and best studied endocrine disruptors. After years of exposure to consumer products containing BPA, most individuals tested have circulating BPA at the low nanomolar levels. In addition to its well documented actions on the reproductive system, BPA exerts a wide variety of metabolic effects. This review summarizes recent findings on the ability of BPA, at environmentally relevant doses, to inhibit adiponectin and stimulate the release of inflammatory adipokines such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFalpha) from human adipose tissue. Expression of several classical and non-classical estrogen receptors in human adipose tissue raises the possibility of their involvement as mediators of BPA actions. The implications of these observations to the obesity-related metabolic syndrome and its sequelae are discussed.
Authors:
Nira Ben-Jonathan; Eric R Hugo; Terry D Brandebourg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2009-03-09
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  304     ISSN:  1872-8057     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-12     Completed Date:  2009-07-28     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  49-54     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipokines / metabolism*
Adiponectin / metabolism
Adipose Tissue* / drug effects,  metabolism
Air Pollutants, Occupational / chemistry,  metabolism,  pharmacology
Animals
Benzhydryl Compounds
Endocrine Disruptors / chemistry,  metabolism,  pharmacology*
Estrogens, Non-Steroidal / chemistry,  metabolism,  pharmacology
Humans
Interleukin-6 / metabolism
Metabolic Syndrome X / metabolism*
Molecular Structure
Obesity / metabolism
Phenols / chemistry,  metabolism,  pharmacology*
Receptors, Estrogen / metabolism
Tumor Necrosis Factor-alpha / metabolism
Grant Support
ID/Acronym/Agency:
CA096613/CA/NCI NIH HHS; ES012212/ES/NIEHS NIH HHS; ES016803/ES/NIEHS NIH HHS; P30 ES06096/ES/NIEHS NIH HHS; R01 CA096613/CA/NCI NIH HHS; R01 CA096613-06/CA/NCI NIH HHS; R01 ES012212/ES/NIEHS NIH HHS; R01 ES012212-04/ES/NIEHS NIH HHS; R21 ES016803/ES/NIEHS NIH HHS; R21 ES016803-01/ES/NIEHS NIH HHS; R21 ES016803-02/ES/NIEHS NIH HHS; R21 ES016803-02S1/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Adipokines; 0/Adiponectin; 0/Air Pollutants, Occupational; 0/Benzhydryl Compounds; 0/Endocrine Disruptors; 0/Estrogens, Non-Steroidal; 0/Interleukin-6; 0/Phenols; 0/Receptors, Estrogen; 0/Tumor Necrosis Factor-alpha; MLT3645I99/bisphenol A
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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