Document Detail

Effects of birth advancement in Chiari malformation in a surgical myelomeningocele model in rabbits.
MedLine Citation:
PMID:  20223326     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/PURPOSE: In myelomeningocele (MMC), Chiari II malformation progresses during gestation because of the continuous loss of cerebrospinal fluid at the site of the defect. Our purpose was to assess the impact of birth advancement (BA) and prenatal corticosteroid treatment (PCT) on Chiari malformation in a surgical MMC model in rabbits. METHODS: A surgical MMC-like defect was created in 75 fetal rabbits. Animals were distributed into 4 groups depending on the treatment received: not treated and those undergoing BA + PCT, BA, or PCT. The degree of Chiari malformation in newborn rabbits was defined as the percentage of downward protrusion of the hindbrain between the end of the occipital bone and the beginning of the first vertebral arch. RESULTS: The degree of hindbrain herniation was 80% (8.15) in the not treated group, 36.8% (10.57) in BA + PCT, 41.8% (8.27) in BA, and 44.4% (8.32) in PCT. The BA + PCT, BA, and PCT groups showed less severe hindbrain herniation than not treated animals (mean decrease, 39.86%; SD, 10.57; P = .000). There were no significant differences between the BA + PCT, BA, and PCT groups (P = .311). CONCLUSIONS: Birth advancement and prenatal administration of corticosteroids decrease the severity of the hindbrain herniation component of Chiari II malformation in surgical MMC in fetal rabbits.
Cesar G Fontecha; Marius Aguire; Francisco Soldado; Jose L Peiro; Nuria Toran; Nuria Vidal; Vicente Martinez
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  45     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-12     Completed Date:  2010-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  594-9     Citation Subset:  IM    
Pediatric Orthopedic Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
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MeSH Terms
Animals, Newborn
Arnold-Chiari Malformation / drug therapy*,  etiology*,  physiopathology
Betamethasone / pharmacology*
Cerebellum / pathology
Confidence Intervals
Disease Models, Animal
Fetal Diseases / mortality,  surgery*
Fetal Mortality
Gestational Age
Meningomyelocele / complications,  mortality,  surgery*
Treatment Outcome
Reg. No./Substance:

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