Document Detail


Effects of bilobalide on cerebral amino acid neurotransmission.
MedLine Citation:
PMID:  13130394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bilobalide is one of many active constituents found in EGb 761 (definition see editorial), which is extracted from Ginkgo biloba leaves. Whilst there is good, sound evidence that bilobalide exhibits neuroprotective actions in a variety of model systems, there is currently no consensus on its mechanism of action. This present communication summarises the results we have obtained with this compound on excitatory amino acid neurotransmission in the central nervous system using both neurochemical and electrophysiological techniques. Bilobalide was shown to reduce glutamate and aspartate release elicited by both high potassium-containing artificial cerebrospinal fluid (aCSF) or veratridine from mouse cortical slices. In addition, bilobalide had a very potent effect (IC (50) 2.7 microM) on glutamate release elicited by hypoxia/hypoglycaemia-induced release from rat cortical slices. Electrophysiologically, bilobalide also decreased the frequency of gamma-aminobutyric acid (GABA) uptake inhibitor-induced depolarisations in mouse cortical slices, an effect probably mediated by a decrease in glutamate release. No definitive conclusions can be reached concerning the mechanism of action of bilobalide, but an ability to decrease excitotoxic amino acid release, particularly glutamate, would suggest that this is a probable mechanism to account for its neuroprotective properties.
Authors:
J A Davies; L Johns; F A Jones
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Pharmacopsychiatry     Volume:  36 Suppl 1     ISSN:  0176-3679     ISO Abbreviation:  Pharmacopsychiatry     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-09-17     Completed Date:  2003-10-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8402938     Medline TA:  Pharmacopsychiatry     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  S84-8     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Therapeutics & Toxicology, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK. daviesja8@cardiff.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Anoxia / metabolism
Cerebral Cortex / drug effects*,  metabolism
Cyclopentanes / pharmacology*
Diterpenes*
Dose-Response Relationship, Drug
Drug Interactions
Epilepsy, Reflex / metabolism
Epilepsy, Tonic-Clonic / drug therapy
Female
Furans / pharmacology*
Ginkgolides
Glutamic Acid / metabolism*
Hypoglycemia / metabolism
Male
Mice
Mice, Inbred BALB C
Mice, Inbred DBA
Neurotransmitter Uptake Inhibitors / pharmacology
Nipecotic Acids / pharmacology
Oximes / pharmacology
Potassium / pharmacology
Rats
Rats, Wistar
Time Factors
Veratridine / pharmacology
Chemical
Reg. No./Substance:
0/Cyclopentanes; 0/Diterpenes; 0/Furans; 0/Ginkgolides; 0/Neurotransmitter Uptake Inhibitors; 0/Nipecotic Acids; 0/Oximes; 145645-62-1/NNC 711; 33570-04-6/bilobalide; 56-86-0/Glutamic Acid; 71-62-5/Veratridine; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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