| Effects of bilobalide on cerebral amino acid neurotransmission. | |
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MedLine Citation:
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PMID: 13130394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bilobalide is one of many active constituents found in EGb 761 (definition see editorial), which is extracted from Ginkgo biloba leaves. Whilst there is good, sound evidence that bilobalide exhibits neuroprotective actions in a variety of model systems, there is currently no consensus on its mechanism of action. This present communication summarises the results we have obtained with this compound on excitatory amino acid neurotransmission in the central nervous system using both neurochemical and electrophysiological techniques. Bilobalide was shown to reduce glutamate and aspartate release elicited by both high potassium-containing artificial cerebrospinal fluid (aCSF) or veratridine from mouse cortical slices. In addition, bilobalide had a very potent effect (IC (50) 2.7 microM) on glutamate release elicited by hypoxia/hypoglycaemia-induced release from rat cortical slices. Electrophysiologically, bilobalide also decreased the frequency of gamma-aminobutyric acid (GABA) uptake inhibitor-induced depolarisations in mouse cortical slices, an effect probably mediated by a decrease in glutamate release. No definitive conclusions can be reached concerning the mechanism of action of bilobalide, but an ability to decrease excitotoxic amino acid release, particularly glutamate, would suggest that this is a probable mechanism to account for its neuroprotective properties. |
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Authors:
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J A Davies; L Johns; F A Jones |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Pharmacopsychiatry Volume: 36 Suppl 1 ISSN: 0176-3679 ISO Abbreviation: Pharmacopsychiatry Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-09-17 Completed Date: 2003-10-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8402938 Medline TA: Pharmacopsychiatry Country: Germany |
Other Details:
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Languages: eng Pagination: S84-8 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Therapeutics & Toxicology, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK. daviesja8@cardiff.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Anoxia / metabolism Cerebral Cortex / drug effects*, metabolism Cyclopentanes / pharmacology* Diterpenes* Dose-Response Relationship, Drug Drug Interactions Epilepsy, Reflex / metabolism Epilepsy, Tonic-Clonic / drug therapy Female Furans / pharmacology* Ginkgolides Glutamic Acid / metabolism* Hypoglycemia / metabolism Male Mice Mice, Inbred BALB C Mice, Inbred DBA Neurotransmitter Uptake Inhibitors / pharmacology Nipecotic Acids / pharmacology Oximes / pharmacology Potassium / pharmacology Rats Rats, Wistar Time Factors Veratridine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Cyclopentanes; 0/Diterpenes; 0/Furans; 0/Ginkgolides; 0/Neurotransmitter Uptake Inhibitors; 0/Nipecotic Acids; 0/Oximes; 145645-62-1/NNC 711; 33570-04-6/bilobalide; 56-86-0/Glutamic Acid; 71-62-5/Veratridine; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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