Document Detail

Effects of bile reflux and intragastric microflora changes on lesions of remnant gastric mucosa after gastric operation.
MedLine Citation:
PMID:  15133869     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate the effects of bile reflux and intragastric microflora changes on lesions of remnant gastric mucosa after gastric operation. METHODS: Concentration of bile acid and total bacterial counts (TBC) in gastric juice were measured in 49 patients with peptic ulcer before and after gastrectomy. One year after the operation, sample of gastric mucosa taken from all the patients were used for histological examination. RESULTS: The concentration of gastric bile acid was significantly increased in group B-I, or B-II and SV+A than that in group HSV (P<0.05-0.01). The abnormal histological changes in the remnant gastric mucosa were more common in the first 2 groups than in the last group. CONCLUSION: The type of gastrectomy can affect bile reflux. The abnormal histological changes in the remnant gastric mucosa are closely related to the elevation of bile acid concentration and increase of TBC in gastric juice. HSV can effectively prevent bile reflux and keep the gastric physiological functions stable.
Chao Zhang; Zhan-Kui Liu; Pei-Wu Yu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  10     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-10     Completed Date:  2005-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  1537-9     Citation Subset:  IM    
Department of General Surgery, Southwest Hospital, Third Military Medical University, Gaotan Yan, Chongqing 400038, China.
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MeSH Terms
Bile Acids and Salts / analysis
Bile Reflux*
Gastrectomy* / adverse effects
Gastric Juice* / chemistry,  microbiology
Gastric Mucosa* / microbiology,  pathology,  surgery
Postgastrectomy Syndromes
Stomach Ulcer / surgery
Reg. No./Substance:
0/Bile Acids and Salts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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